7UPE
 
 | | Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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7UPF
 | | Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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7UPG
 | | Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours | | Descriptor: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2022-04-15 | | Release date: | 2022-09-28 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
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7SP1
 | | RNA-induced tau amyloid fibril | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | | Authors: | Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S. | | Deposit date: | 2021-11-02 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7MKF
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7MKH
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7MKG
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6XLI
 | | CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE | | Descriptor: | GLYCEROL, PT3 Fab Heavy Chain, PT3 Fab Light Chain, ... | | Authors: | Malia, T.J, Teplyakov, A, Luo, J. | | Deposit date: | 2020-06-28 | | Release date: | 2020-09-23 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody.
J Alzheimers Dis, 77, 2020
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6VHL
 | | Paired Helical Filament from Alzheimer's Disease Human Brain Tissue | | Descriptor: | GLYCINE, Microtubule-associated protein tau | | Authors: | Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. | | Deposit date: | 2020-01-10 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains.
Cell, 180, 2020
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4NP8
 | | Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) | | Descriptor: | Microtubule-associated protein tau | | Authors: | Landau, M, Eisenberg, D, Sawaya, M.R, Dannenberg, J, Kobko, N. | | Deposit date: | 2013-11-20 | | Release date: | 2013-12-18 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Molecular mechanisms for protein-encoded inheritance.
Nat.Struct.Mol.Biol., 16, 2009
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5K7N
 | | MicroED structure of tau VQIVYK peptide at 1.1 A resolution | | Descriptor: | VQIVYK | | Authors: | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | Deposit date: | 2016-05-26 | | Release date: | 2017-04-05 | | Last modified: | 2024-02-28 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | Cite: | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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1I8H
 | | SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH HUMAN TAU PHOSPHOTHREONINE PEPTIDE | | Descriptor: | MICROTUBULE-ASSOCIATED PROTEIN TAU, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 | | Authors: | Wintjens, R, Wieruszeski, J.-M, Drobecq, H, Lippens, G, Landrieu, I. | | Deposit date: | 2001-03-14 | | Release date: | 2001-07-18 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides.
J.Biol.Chem., 276, 2001
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7EYC
 | | Crystal structure of Tau and acetylated tau peptide antigen | | Descriptor: | ACETYLATED TAU PEPTIDE, antibody, Heavy chain, ... | | Authors: | Hong, M, Park, J. | | Deposit date: | 2021-05-30 | | Release date: | 2022-06-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.
J.Clin.Invest., 133, 2023
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3OVL
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7KQK
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9MR8
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8WCP
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6TJO
 | | Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration | | Descriptor: | Microtubule-associated protein tau | | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2019-11-26 | | Release date: | 2020-02-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
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7YMN
 | | Cryo-EM structure of in vitro PHF fibril | | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | | Authors: | Li, X, Liu, C. | | Deposit date: | 2022-07-28 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure.
Iscience, 25, 2022
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7YPG
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6TJX
 | | Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration | | Descriptor: | Microtubule-associated protein tau | | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2019-11-27 | | Release date: | 2020-02-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
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8FNZ
 | | Acetylated tau repeat 1 and 2 fragment (AcR1R2) | | Descriptor: | Microtubule-associated protein tau, acetylated repeat 1 and 2 fragment | | Authors: | Li, L, Nguyen, A.B, Mullapudi, V, Joachimiak, L. | | Deposit date: | 2022-12-29 | | Release date: | 2023-06-28 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Disease-associated patterns of acetylation stabilize tau fibril formation.
Structure, 31, 2023
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5V5C
 | | VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2 | | Descriptor: | Microtubule-associated protein tau | | Authors: | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | Deposit date: | 2017-03-14 | | Release date: | 2018-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.25 Å) | | Cite: | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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8FUG
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8V1N
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