8FUG

Alzheimer's disease paired-helical filament in complex with PET tracer GTP-1

Summary for 8FUG

Entry DOI	10.2210/pdb8fug/pdb
EMDB information	29458
Descriptor	Microtubule-associated protein tau, (5S)-2-[4-(2-fluoroethyl)piperidin-1-yl]pyrimido[1,2-a]benzimidazole (2 entities in total)
Functional Keywords	neurodegeneration, positron emission tomography, filament, alzheimer's disease, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	23
Total formula weight	189485.48
Authors	Merz, G.E.,Tse, E.,Southworth, D.R. (deposition date: 2023-01-17, release date: 2023-06-07, Last modification date: 2024-06-19)
Primary citation	Merz, G.E.,Chalkley, M.J.,Tan, S.K.,Tse, E.,Lee, J.,Prusiner, S.B.,Paras, N.A.,DeGrado, W.F.,Southworth, D.R. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nat Commun, 14:3048-3048, 2023 Cited by PubMed: 37236970 DOI: 10.1038/s41467-023-38537-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation