8FUG

Alzheimer's disease paired-helical filament in complex with PET tracer GTP-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008017	molecular_function	microtubule binding
A	0015631	molecular_function	tubulin binding
B	0008017	molecular_function	microtubule binding
B	0015631	molecular_function	tubulin binding
C	0008017	molecular_function	microtubule binding
C	0015631	molecular_function	tubulin binding
D	0008017	molecular_function	microtubule binding
D	0015631	molecular_function	tubulin binding
E	0008017	molecular_function	microtubule binding
E	0015631	molecular_function	tubulin binding
F	0008017	molecular_function	microtubule binding
F	0015631	molecular_function	tubulin binding
G	0008017	molecular_function	microtubule binding
G	0015631	molecular_function	tubulin binding
H	0008017	molecular_function	microtubule binding
H	0015631	molecular_function	tubulin binding
I	0008017	molecular_function	microtubule binding
I	0015631	molecular_function	tubulin binding
J	0008017	molecular_function	microtubule binding
J	0015631	molecular_function	tubulin binding
K	0008017	molecular_function	microtubule binding
K	0015631	molecular_function	tubulin binding
L	0008017	molecular_function	microtubule binding
L	0015631	molecular_function	tubulin binding
M	0008017	molecular_function	microtubule binding
M	0015631	molecular_function	tubulin binding
N	0008017	molecular_function	microtubule binding
N	0015631	molecular_function	tubulin binding
O	0008017	molecular_function	microtubule binding
O	0015631	molecular_function	tubulin binding
P	0008017	molecular_function	microtubule binding
P	0015631	molecular_function	tubulin binding
Q	0008017	molecular_function	microtubule binding
Q	0015631	molecular_function	tubulin binding
R	0008017	molecular_function	microtubule binding
R	0015631	molecular_function	tubulin binding
S	0008017	molecular_function	microtubule binding
S	0015631	molecular_function	tubulin binding
T	0008017	molecular_function	microtubule binding
T	0015631	molecular_function	tubulin binding
U	0008017	molecular_function	microtubule binding
U	0015631	molecular_function	tubulin binding
V	0008017	molecular_function	microtubule binding
V	0015631	molecular_function	tubulin binding
W	0008017	molecular_function	microtubule binding
W	0015631	molecular_function	tubulin binding

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSlgNihHkPGGG

Chain	Residue	Details
A	GLY323-GLY335
A	GLY355-GLY367

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	690
Details	Repeat: {"description":"Tau/MAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	713
Details	Repeat: {"description":"Tau/MAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	184
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	161
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	23
Details	Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	69
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	46
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	46
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	138
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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