7UPF

Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG

Summary for 7UPF

Entry DOI	10.2210/pdb7upf/pdb
EMDB information	26664
Descriptor	Isoform Tau-F of Microtubule-associated protein tau (1 entity in total)
Functional Keywords	amyloid, fibril, alzheimer's, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	459198.71
Authors	Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2022-04-15, release date: 2022-09-28)
Primary citation	Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Hu, C.J.,Cheng, X.,Abskharon, R.,Pan, H.,DeTure, M.A.,Williams, C.K.,Dickson, D.W.,Vinters, H.V.,Eisenberg, D.S. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13:5451-5451, 2022 Cited by PubMed: 36114178 DOI: 10.1038/s41467-022-32951-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation