7SP1
RNA-induced tau amyloid fibril
Summary for 7SP1
Entry DOI | 10.2210/pdb7sp1/pdb |
EMDB information | 25364 |
Descriptor | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') (2 entities in total) |
Functional Keywords | amyloid fibril, complex, protein fibril-rna complex, protein fibril/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 17 |
Total formula weight | 695292.26 |
Authors | Abskharon, R.,Sawaya, M.R.,Boyer, D.R.,Eisenberg, D.S. (deposition date: 2021-11-02, release date: 2022-03-30, Last modification date: 2024-06-05) |
Primary citation | Abskharon, R.,Sawaya, M.R.,Boyer, D.R.,Cao, Q.,Nguyen, B.A.,Cascio, D.,Eisenberg, D.S. Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc.Natl.Acad.Sci.USA, 119:e2119952119-e2119952119, 2022 Cited by PubMed: 35377792DOI: 10.1073/pnas.2119952119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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