7SP1

RNA-induced tau amyloid fibril

Summary for 7SP1

• Entry DOI: 10.2210/pdb7sp1/pdb
• EMDB information: 25364
• Descriptor: Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') (2 entities in total)
• Functional Keywords: amyloid fibril, complex, protein fibril-rna complex, protein fibril/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 17
• Total formula weight: 695292.26

Authors

Abskharon, R.,Sawaya, M.R.,Boyer, D.R.,Eisenberg, D.S. (deposition date: 2021-11-02, release date: 2022-03-30, Last modification date: 2022-06-22)

• Primary citation: Abskharon, R.,Sawaya, M.R.,Boyer, D.R.,Cao, Q.,Nguyen, B.A.,Cascio, D.,Eisenberg, D.S.; Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.; Proc.Natl.Acad.Sci.USA, 119:e2119952119-e2119952119, 2022; PubMed: 35377792; DOI: 10.1073/pnas.2119952119

Experimental method

ELECTRON MICROSCOPY (3.4 Å)