7UPG

Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours

Summary for 7UPG

• Entry DOI: 10.2210/pdb7upg/pdb
• Related: 7UPE 7UPF
• EMDB information: 26665
• Descriptor: Isoform Tau-F of Microtubule-associated protein tau, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate (2 entities in total)
• Functional Keywords: amyloid, fibril, alzheimer's, disease, disaggregant, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 463782.43

Authors

Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2022-04-15, release date: 2022-09-28)

• Primary citation: Seidler, P.M.,Murray, K.A.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Hu, C.J.,Cheng, X.,Abskharon, R.,Pan, H.,DeTure, M.A.,Williams, C.K.,Dickson, D.W.,Vinters, H.V.,Eisenberg, D.S.; Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.; Nat Commun, 13:5451-5451, 2022; PubMed: 36114178; DOI: 10.1038/s41467-022-32951-4

Experimental method

ELECTRON MICROSCOPY (3.8 Å)