7EYC

Crystal structure of Tau and acetylated tau peptide antigen

Summary for 7EYC

• Entry DOI: 10.2210/pdb7eyc/pdb
• Descriptor: antibody, light chain, antibody, Heavy chain, ACETYLATED TAU PEPTIDE, ... (4 entities in total)
• Functional Keywords: antibody, tau, alzheime disease, protein binding, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 95154.54

Authors

Hong, M.,Park, J. (deposition date: 2021-05-30, release date: 2022-06-01, Last modification date: 2023-11-29)

• Primary citation: Song, H.L.,Kim, N.Y.,Park, J.,Kim, M.I.,Jeon, Y.N.,Lee, S.J.,Cho, K.,Shim, Y.L.,Lee, K.H.,Mun, Y.S.,Song, J.A.,Kim, M.S.,Pack, C.G.,Jung, M.,Jang, H.,Na, D.L.,Hong, M.,Kim, D.H.,Yoon, S.Y.; Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.; J.Clin.Invest., 133:-, 2023; PubMed: 36917188; DOI: 10.1172/JCI156537

Experimental method

X-RAY DIFFRACTION (2.49 Å)