6XLI
CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE
Summary for 6XLI
Entry DOI | 10.2210/pdb6xli/pdb |
Descriptor | PT3 Fab Heavy Chain, PT3 Fab Light Chain, Tau Phosphopeptide (Ac-SR(pT)PSLP(pT)PPTRE-OH), ... (5 entities in total) |
Functional Keywords | immunoglobulin fold, antibody, immune system, neuroscience |
Biological source | Mus musculus More |
Total number of polymer chains | 9 |
Total formula weight | 150377.73 |
Authors | Malia, T.J.,Teplyakov, A.,Luo, J. (deposition date: 2020-06-28, release date: 2020-09-23, Last modification date: 2023-10-18) |
Primary citation | Van Kolen, K.,Malia, T.J.,Theunis, C.,Nanjunda, R.,Teplyakov, A.,Ernst, R.,Wu, S.J.,Luo, J.,Borgers, M.,Vandermeeren, M.,Bottelbergs, A.,Wintmolders, C.,Lacy, E.,Maurin, H.,Larsen, P.,Willems, R.,Van De Casteele, T.,Triana-Baltzer, G.,Slemmon, R.,Galpern, W.,Trojanowski, J.Q.,Sun, H.,Mercken, M.H. Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. J Alzheimers Dis, 77:1397-1416, 2020 Cited by PubMed: 32894244DOI: 10.3233/JAD-200544 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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