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PDB: 114 results
8FTO
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BU of 8fto by Molmil
E. coli 70S ribosome with an improved MS2 tag inserted in H98
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Nissley, A.J, Cate, J.H.D.
Deposit date:2023-01-12
Release date:2023-08-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (1.85 Å)
Cite:Interactions between terminal ribosomal RNA helices stabilize the E. coli large ribosomal subunit.
Rna, 29, 2023
8E30
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BU of 8e30 by Molmil
E. coli 50S ribosome bound to compound streptogramin A analog 3142
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-16
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (1.91 Å)
Cite:Potential for clicked streptogramin analogs
To Be Published
7K00
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BU of 7k00 by Molmil
Structure of the Bacterial Ribosome at 2 Angstrom Resolution
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Watson, Z.L, Ward, F.R, Meheust, R, Ad, O, Schepartz, A, Banfield, J.F, Cate, J.H.D.
Deposit date:2020-09-02
Release date:2020-09-23
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structure of the bacterial ribosome at 2 angstrom resolution.
Elife, 9, 2020
8E3O
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BU of 8e3o by Molmil
E. coli 50S ribosome bound to solithromycin and VM1
Descriptor: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (1.99 Å)
Cite:Solithromycin siderophore conjugates
To Be Published
8G6W
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BU of 8g6w by Molmil
Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe
Descriptor: 16S rRNA, 2-AMINO-BENZAMIDE, 23S rRNA, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-04-05
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.02 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8E49
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E. coli 50S ribosome bound to antibiotic analog SLC31
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.05 Å)
Cite:SLC collection of antibiotic analogs
To Be Published
8G6Y
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BU of 8g6y by Molmil
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe
Descriptor: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminopyridine-4-carboxamide, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-04-05
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.09 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8E43
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BU of 8e43 by Molmil
E. coli 50S ribosome bound to compound streptogramin A analog 3336
Descriptor: (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-4-(prop-2-en-1-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Seiple, I.B, Fraser, J.S.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.09 Å)
Cite:Streptogramin A analogs
To Be Published
8EMM
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BU of 8emm by Molmil
Composite 70S ribosome structure for "Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Watson, Z.L, Cate, J.H.D.
Deposit date:2022-09-28
Release date:2023-05-31
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates.
Nat.Chem., 15, 2023
8E41
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BU of 8e41 by Molmil
E. coli 50S ribosome bound to tiamulin and VS1
Descriptor: 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.13 Å)
Cite:Tiamulin and NPET binders
To Be Published
6PJ6
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BU of 6pj6 by Molmil
High resolution cryo-EM structure of E.coli 50S
Descriptor: 23S rRNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ...
Authors:Stojkovic, V, Myasnikov, A, Frost, A, Fujimori, D.G.
Deposit date:2019-06-27
Release date:2020-01-22
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.
Nucleic Acids Res., 48, 2020
7LVK
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BU of 7lvk by Molmil
Cfr-modified 50S subunit from Escherichia coli
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Stojkovic, V, Myasnikov, A.G, Frost, A, Fujimori, D.G.
Deposit date:2021-02-25
Release date:2021-12-15
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Investigating antibiotic resistance of a ribosomal-RNA methylating enzyme through directed evolution
To Be Published
8E33
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BU of 8e33 by Molmil
E. coli 50S ribosome bound to compound streptogramin analog SAB001
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-16
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (2.23 Å)
Cite:Potential for clicked streptogramin analogs
To Be Published
8EIU
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BU of 8eiu by Molmil
E. coli 70S ribosome with A-loop mutations U2554C and U2555C
Descriptor: 16S rRNA, 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ...
Authors:Nissley, A.J, Penev, P.I, Watson, Z.L, Banfield, J.F, Cate, J.H.D.
Deposit date:2022-09-15
Release date:2023-02-01
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.24 Å)
Cite:Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome.
Nucleic Acids Res., 51, 2023
8E3M
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BU of 8e3m by Molmil
E. coli 50S ribosome bound to L-linker solithromycin conjugate
Descriptor: 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.25 Å)
Cite:Solithromycin siderophore conjugates
To Be Published
8E35
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BU of 8e35 by Molmil
E. coli 50S ribosome bound to compound SAB002
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-16
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.27 Å)
Cite:Potential for clicked streptogramin analogs
To Be Published
8E48
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BU of 8e48 by Molmil
E. coli 50S ribosome bound to antibiotic analog SLC30
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.27 Å)
Cite:SLC collection of antibiotic analogs
To Be Published
8E42
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BU of 8e42 by Molmil
E. coli 50S ribosome bound to tiamulin and azithromycin
Descriptor: 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:Tiamulin and NPET binders
To Be Published
8E45
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BU of 8e45 by Molmil
E. coli 50S ribosome bound to antibiotic analog SLC17
Descriptor: 2-{[(2S,3R,4S,6R)-2-{[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl]oxy}-3-hydroxy-6-methyloxan-4-yl](methyl)amino}-N-{[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (non-preferred name), 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:SLC collection of antibiotic analogs
To Be Published
8G6X
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BU of 8g6x by Molmil
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe
Descriptor: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminobenzamide, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-03-22
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8E47
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E. coli 50S ribosome bound to antibiotic analog SLC26
Descriptor: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-({3,4,6-trideoxy-3-[(2-{[2-({[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-oxoethyl]sulfanyl}ethyl)(methyl)amino]-beta-D-xylo-hexopyranosyl}oxy)-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:SLC collection of antibiotic analogs
To Be Published
8E46
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BU of 8e46 by Molmil
E. coli 50S ribosome bound to antibiotic analog SLC21
Descriptor: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-({3,4,6-trideoxy-3-[{[1-(2-{[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]amino}-2-oxoethyl)-1H-1,2,3-triazol-4-yl]methyl}(methyl)amino]-beta-D-xylo-hexopyranosyl}oxy)-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.32 Å)
Cite:SLC collection of antibiotic analogs
To Be Published
7S1H
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BU of 7s1h by Molmil
Wild-type Escherichia coli ribosome with antibiotic linezolid
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D.
Deposit date:2021-09-02
Release date:2021-11-17
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Nat.Struct.Mol.Biol., 29, 2022
8E32
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BU of 8e32 by Molmil
E. coli 50S ribosome bound to compound streptogramin analogs SA1 and SB1
Descriptor: (3R,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-yn-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-16
Release date:2023-06-28
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:Potential for clicked streptogramin analogs
To Be Published
8E3L
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E. coli 50S ribosome bound to D-linker solithromycin conjugate
Descriptor: (2~{R})-~{N}-[(2~{R})-6-azanyl-1-[[(2~{R})-1-[[(2~{R})-1-[[3-[1-[4-[(1~{S},2~{R},5~{S},7~{R},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-5-fluoranyl-9-methoxy-1,5,7,11,13-pentamethyl-4,6,12,16-tetrakis(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-15-yl]butyl]-1,2,3-triazol-4-yl]phenyl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]-1-[(2~{R})-2-[[(2~{R})-2-[2-[[2,3-bis(oxidanyl)phenyl]carbonyl-[4-[[2,3-bis(oxidanyl)phenyl]carbonylamino]butyl]amino]ethanoylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-oxidanyl-propanoyl]pyrrolidine-2-carboxamide, 50S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:2022-08-17
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:Solithromycin siderophore conjugates
To Be Published

222624

PDB entries from 2024-07-17

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