8E35

E. coli 50S ribosome bound to compound SAB002

Summary for 8E35

Entry DOI	10.2210/pdb8e35/pdb
EMDB information	27852 27854 27855 27857 27858
Descriptor	23S ribosomal RNA, 50S ribosomal protein L34, N-{(4R,6R,9S,10R,13S,15aS,17R,20R,22S,24aS)-22-benzyl-6-[3-(4-{[(3R,4R,5E,10E,12E,14S,16R,23R,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-3-(propan-2-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-4-yl]methyl}-1H-1,2,3-triazol-1-yl)propyl]-17-hydroxy-10,23-dimethyl-5,8,12,15,21,24-hexaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl}-3-hydroxypyridine-2-carboxamide, ... (12 entities in total)
Functional Keywords	e. coli ribosome, streptogramin a, streptogramin b, antibiotics, ribosome-antibiotic complex, ribosome/antibiotic
Biological source	Escherichia coli More
Total number of polymer chains	10
Total formula weight	1110514.40
Authors	Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. (deposition date: 2022-08-16, release date: 2023-06-28)
Primary citation	Takahashi, Y.,Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. Potential for clicked streptogramin analogs To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.27 Å)

Structure validation