8E45

E. coli 50S ribosome bound to antibiotic analog SLC17

Summary for 8E45

Entry DOI	10.2210/pdb8e45/pdb
EMDB information	27880
Descriptor	23S ribosomal RNA, 50S ribosomal protein L34, 2-{[(2S,3R,4S,6R)-2-{[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl]oxy}-3-hydroxy-6-methyloxan-4-yl](methyl)amino}-N-{[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (non-preferred name), ... (11 entities in total)
Functional Keywords	e. coli ribosome, antibiotics, ribosome
Biological source	Escherichia coli More
Total number of polymer chains	10
Total formula weight	1110222.15
Authors	Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. (deposition date: 2022-08-17, release date: 2023-06-28)
Primary citation	Yeon, S.K.,Pellegrino, J.,Lee, D.J.,Seiple, I.B.,Fraser, J.S. SLC collection of antibiotic analogs To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.3 Å)

Structure validation