8E3L

E. coli 50S ribosome bound to D-linker solithromycin conjugate

This is a non-PDB format compatible entry.

Summary for 8E3L

• Entry DOI: 10.2210/pdb8e3l/pdb
• EMDB information: 27867
• Descriptor: 50S ribosomal RNA, 50S ribosomal protein L34, (2~{R})-~{N}-[(2~{R})-6-azanyl-1-[[(2~{R})-1-[[(2~{R})-1-[[3-[1-[4-[(1~{S},2~{R},5~{S},7~{R},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-5-fluoranyl-9-methoxy-1,5,7,11,13-pentamethyl-4,6,12,16-tetrakis(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-15-yl]butyl]-1,2,3-triazol-4-yl]phenyl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]-1-[(2~{R})-2-[[(2~{R})-2-[2-[[2,3-bis(oxidanyl)phenyl]carbonyl-[4-[[2,3-bis(oxidanyl)phenyl]carbonylamino]butyl]amino]ethanoylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-oxidanyl-propanoyl]pyrrolidine-2-carboxamide, ... (11 entities in total)
• Functional Keywords: e. coli ribosome, solithromycin, siderophore conjugate, antibiotics, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 10
• Total formula weight: 1111102.12

Authors

Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. (deposition date: 2022-08-17, release date: 2023-06-28)

• Primary citation: Boyce, J.H.,Pellegrino, J.,Lee, D.J.,Ecker, A.K.,Seiple, I.B.,Fraser, J.S.; Solithromycin siderophore conjugates; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.35 Å)