8E47

E. coli 50S ribosome bound to antibiotic analog SLC26

Summary for 8E47

Entry DOI	10.2210/pdb8e47/pdb
EMDB information	27882
Descriptor	23S ribosomal RNA, 50S ribosomal protein L34, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-({3,4,6-trideoxy-3-[(2-{[2-({[(5S)-3-{(4M)-3-fluoro-4-[(6P)-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-oxoethyl]sulfanyl}ethyl)(methyl)amino]-beta-D-xylo-hexopyranosyl}oxy)-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside, ... (11 entities in total)
Functional Keywords	antibiotics, ribosome
Biological source	Escherichia coli More
Total number of polymer chains	10
Total formula weight	1110282.27
Authors	Pellegrino, J.,Lee, D.J.,Fraser, J.S.,Seiple, I.B. (deposition date: 2022-08-17, release date: 2023-06-28, Last modification date: 2024-06-12)
Primary citation	Yeon, S.K.,Pellegrino, J.,Lee, D.J.,Seiple, I.B.,Fraser, J.S. SLC collection of antibiotic analogs To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.32 Å)

Structure validation