8X16
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![BU of 8x16 by Molmil](/molmil-images/mine/8x16) | Cryo-EM structure of adenosine receptor A3AR bound to CF101 | Descriptor: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cai, H, Xu, Y, Xu, H.E. | Deposit date: | 2023-11-06 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists. Nat Commun, 15, 2024
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8ZMG
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![BU of 8zmg by Molmil](/molmil-images/mine/8zmg) | Crystal structure of an inverse agonist antipsychotic drug pimavanserin-bound 5-HT2A | Descriptor: | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, Pimavanserin | Authors: | Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K. | Deposit date: | 2024-05-23 | Release date: | 2024-08-28 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J.Med.Chem., 67, 2024
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9ERX
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![BU of 9erx by Molmil](/molmil-images/mine/9erx) | Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor | Descriptor: | (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, Antibody ScFv16 Fab fragment, Cannabinoid receptor 1, ... | Authors: | Thorsen, T.S, Kulkarni, Y, Boggild, A, Drace, T, Nissen, P, Gajhede, M, Boesen, T, Kastrup, J.S, Gloriam, D. | Deposit date: | 2024-03-25 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of Delta 9 -THC analog activity at the Cannabinoid 1 receptor. Res Sq, 2024
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8X2K
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![BU of 8x2k by Molmil](/molmil-images/mine/8x2k) | a lipid receptor complex structure | Descriptor: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Geng, C, Yang, D, Jun, X. | Deposit date: | 2023-11-09 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | a lipid receptor complex structure To Be Published
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8ZJD
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![BU of 8zjd by Molmil](/molmil-images/mine/8zjd) | Cryo-EM structure of kisspeptin receptor bound to KP-10 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, ... | Authors: | Shen, S, Liu, H, Xu, H.E. | Deposit date: | 2024-05-14 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Cryo-EM structure of kisspeptin receptor bound to KP-10 To Be Published
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9BKJ
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![BU of 9bkj by Molmil](/molmil-images/mine/9bkj) | Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex | Descriptor: | AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ... | Authors: | Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | Deposit date: | 2024-04-29 | Release date: | 2024-05-22 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
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8WZ2
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![BU of 8wz2 by Molmil](/molmil-images/mine/8wz2) | Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex | Descriptor: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y. | Deposit date: | 2023-11-01 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell Discov, 10, 2024
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8YUV
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![BU of 8yuv by Molmil](/molmil-images/mine/8yuv) | Cryo-EM structure of the immepip-bound H3R-Gi complex | Descriptor: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | Deposit date: | 2024-03-27 | Release date: | 2024-06-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8YUU
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![BU of 8yuu by Molmil](/molmil-images/mine/8yuu) | Cryo-EM structure of the histamine-bound H3R-Gi complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | Deposit date: | 2024-03-27 | Release date: | 2024-06-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8YKW
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![BU of 8ykw by Molmil](/molmil-images/mine/8ykw) | Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | Deposit date: | 2024-03-05 | Release date: | 2024-05-29 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell Res., 34, 2024
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8GAG
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![BU of 8gag by Molmil](/molmil-images/mine/8gag) | Cannabinoid receptor 1-Gi complex with novel ligand | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Tummino, T.A, Iliopoulos-Tsoutsouvas, C, Braz, J.M, O'Brien, E.S, Krishna Kumar, K, Makriyannis, M, Basbaum, A.I, Shoichet, B.K. | Deposit date: | 2023-02-22 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cannabinoid receptor 1-Gi complex with novel ligand To Be Published
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8GDZ
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![BU of 8gdz by Molmil](/molmil-images/mine/8gdz) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#1 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE1
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![BU of 8ge1 by Molmil](/molmil-images/mine/8ge1) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#2 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE2
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![BU of 8ge2 by Molmil](/molmil-images/mine/8ge2) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#3 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE3
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![BU of 8ge3 by Molmil](/molmil-images/mine/8ge3) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#4 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE4
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![BU of 8ge4 by Molmil](/molmil-images/mine/8ge4) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#5 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE5
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![BU of 8ge5 by Molmil](/molmil-images/mine/8ge5) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#6 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE6
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![BU of 8ge6 by Molmil](/molmil-images/mine/8ge6) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#7 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE8
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![BU of 8ge8 by Molmil](/molmil-images/mine/8ge8) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#9 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE7
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![BU of 8ge7 by Molmil](/molmil-images/mine/8ge7) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#8 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GE9
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![BU of 8ge9 by Molmil](/molmil-images/mine/8ge9) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#10 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GEA
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![BU of 8gea by Molmil](/molmil-images/mine/8gea) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#11 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GEB
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![BU of 8geb by Molmil](/molmil-images/mine/8geb) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#12 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GEC
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![BU of 8gec by Molmil](/molmil-images/mine/8gec) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#13 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8GEE
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![BU of 8gee by Molmil](/molmil-images/mine/8gee) | CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#15 of 20) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-03-06 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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