8TB7
Cryo-EM Structure of GPR61-
Summary for 8TB7
Entry DOI | 10.2210/pdb8tb7/pdb |
EMDB information | 41145 |
Descriptor | G-protein coupled receptor 61,Soluble cytochrome b562, Fab24 BAK5 heavy chain, Fab hinge-binding nanobody, ... (6 entities in total) |
Functional Keywords | gpcr, inverse agonist, membrane protein, bril, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 150079.25 |
Authors | |
Primary citation | Lees, J.A.,Dias, J.M.,Rajamohan, F.,Fortin, J.P.,O'Connor, R.,Kong, J.X.,Hughes, E.A.G.,Fisher, E.L.,Tuttle, J.B.,Lovett, G.,Kormos, B.L.,Unwalla, R.J.,Zhang, L.,Dechert Schmitt, A.M.,Zhou, D.,Moran, M.,Stevens, K.A.,Fennell, K.F.,Varghese, A.E.,Maxwell, A.,Cote, E.E.,Zhang, Y.,Han, S. An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14:5938-5938, 2023 Cited by PubMed: 37741852DOI: 10.1038/s41467-023-41646-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.94 Å) |
Structure validation
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