8TB7
Cryo-EM Structure of GPR61-
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | G-protein coupled receptor 61,Soluble cytochrome b562 | polymer | 543 | 59991.9 | 1 | UniProt (Q9BZJ8) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (human) | |
| 2 | B (H) | Fab24 BAK5 heavy chain | polymer | 490 | 52888.2 | 1 | Homo sapiens (human) | ||
| 3 | C (N) | Fab hinge-binding nanobody | polymer | 122 | 13276.5 | 1 | Lama glama | ||
| 4 | D (L) | Fab24 BAK5 light chain | polymer | 214 | 23398.1 | 1 | Homo sapiens (human) | ||
| 5 | E (R) | 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide | non-polymer | 524.5 | 1 | Chemie (ZOB) | |||
| 6 | F (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
R: 11 - 242 (UniProt: Q9BZJ8)
R: 248 - 352 (UniProt: P0ABE7)
R: 365 - 532 (UniProt: Q9BZJ8)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Tyr 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Tyr 4 | - | expression tag |
| Asp 5 | - | expression tag |
| Val 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Tyr 9 | - | expression tag |
| Ala 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 254 | Met 29 | conflict |
| Ile 349 | His 124 | conflict |
| Leu 353 | - | linker |
| Glu 354 | - | linker |
| Arg 355 | - | linker |
| Ala 356 | - | linker |
| Arg 357 | - | linker |
| Ser 358 | - | linker |
| Thr 359 | - | linker |
| Leu 360 | - | linker |
| Gln 361 | - | linker |
| Lys 362 | - | linker |
| Glu 363 | - | linker |
| Val 364 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 243 | - | linker |
| Arg 244 | - | linker |
| Arg 245 | - | linker |
| Gln 246 | - | linker |
| Leu 247 | - | linker |
| Gly 533 | - | expression tag |
| Ser 534 | - | expression tag |
| Asp 535 | - | expression tag |
| Tyr 536 | - | expression tag |
| Lys 537 | - | expression tag |
| Asp 538 | - | expression tag |
| Asp 539 | - | expression tag |
| Asp 540 | - | expression tag |
| Asp 541 | - | expression tag |
| Ala 542 | - | expression tag |
| Lys 543 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149554.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 524.5 | |
| All* | Total formula weight | 150079.3 |
