7YXA

XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608

Summary for 7YXA

• Entry DOI: 10.2210/pdb7yxa/pdb
• Descriptor: Sphingosine 1-phosphate receptor 5,Soluble cytochrome b562, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... (6 entities in total)
• Functional Keywords: gpcr, g-protein coupled receptor, xfel, x-ray free electron laser, serial femtosecond crystallography, sfx, sphingosine-1-phosphate, sphingosine-1-phosphate receptor, s1p5, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 102731.20

Authors

Lyapina, E.,Marin, E.,Gusach, A.,Orekhov, P.,Gerasimov, A.,Luginina, A.,Vakhrameev, D.,Ergasheva, M.,Kovaleva, M.,Khusainov, G.,Khorn, P.,Shevtsov, M.,Kovalev, K.,Okhrimenko, I.,Bukhdruker, S.,Popov, P.,Hu, H.,Weierstall, U.,Liu, W.,Cho, Y.,Gushchin, I.,Rogachev, A.,Bourenkov, G.,Park, S.,Park, G.,Huyn, H.J.,Park, J.,Gordeliy, V.,Borshchevskiy, V.,Mishin, A.,Cherezov, V. (deposition date: 2022-02-15, release date: 2022-08-10, Last modification date: 2024-02-07)

• Primary citation: Lyapina, E.,Marin, E.,Gusach, A.,Orekhov, P.,Gerasimov, A.,Luginina, A.,Vakhrameev, D.,Ergasheva, M.,Kovaleva, M.,Khusainov, G.,Khorn, P.,Shevtsov, M.,Kovalev, K.,Bukhdruker, S.,Okhrimenko, I.,Popov, P.,Hu, H.,Weierstall, U.,Liu, W.,Cho, Y.,Gushchin, I.,Rogachev, A.,Bourenkov, G.,Park, S.,Park, G.,Hyun, H.J.,Park, J.,Gordeliy, V.,Borshchevskiy, V.,Mishin, A.,Cherezov, V.; Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors.; Nat Commun, 13:4736-4736, 2022; PubMed: 35961984; DOI: 10.1038/s41467-022-32447-1

Experimental method

X-RAY DIFFRACTION (2.2 Å)