7YXA
XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608
Summary for 7YXA
Entry DOI | 10.2210/pdb7yxa/pdb |
Descriptor | Sphingosine 1-phosphate receptor 5,Soluble cytochrome b562, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... (6 entities in total) |
Functional Keywords | gpcr, g-protein coupled receptor, xfel, x-ray free electron laser, serial femtosecond crystallography, sfx, sphingosine-1-phosphate, sphingosine-1-phosphate receptor, s1p5, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 102731.20 |
Authors | Lyapina, E.,Marin, E.,Gusach, A.,Orekhov, P.,Gerasimov, A.,Luginina, A.,Vakhrameev, D.,Ergasheva, M.,Kovaleva, M.,Khusainov, G.,Khorn, P.,Shevtsov, M.,Kovalev, K.,Okhrimenko, I.,Bukhdruker, S.,Popov, P.,Hu, H.,Weierstall, U.,Liu, W.,Cho, Y.,Gushchin, I.,Rogachev, A.,Bourenkov, G.,Park, S.,Park, G.,Huyn, H.J.,Park, J.,Gordeliy, V.,Borshchevskiy, V.,Mishin, A.,Cherezov, V. (deposition date: 2022-02-15, release date: 2022-08-10, Last modification date: 2024-02-07) |
Primary citation | Lyapina, E.,Marin, E.,Gusach, A.,Orekhov, P.,Gerasimov, A.,Luginina, A.,Vakhrameev, D.,Ergasheva, M.,Kovaleva, M.,Khusainov, G.,Khorn, P.,Shevtsov, M.,Kovalev, K.,Bukhdruker, S.,Okhrimenko, I.,Popov, P.,Hu, H.,Weierstall, U.,Liu, W.,Cho, Y.,Gushchin, I.,Rogachev, A.,Bourenkov, G.,Park, S.,Park, G.,Hyun, H.J.,Park, J.,Gordeliy, V.,Borshchevskiy, V.,Mishin, A.,Cherezov, V. Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13:4736-4736, 2022 Cited by PubMed: 35961984DOI: 10.1038/s41467-022-32447-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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