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6N9D
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BU of 6n9d by Molmil
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Descriptor: CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ...
Authors:Raeeszadeh-Sarmazdeh, M, Radisky, E.S, Sankaran, B.
Deposit date:2018-12-03
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition.
J.Biol.Chem., 294, 2019
8UDZ
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BU of 8udz by Molmil
The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ...
Authors:Streich Jr, F.C, Nicholls, S.B, Boston, C.J, Ramachandran, S.
Deposit date:2023-09-29
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis.
Sci.Signal., 17, 2024
7NWH
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BU of 7nwh by Molmil
Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.
Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
8VG1
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BU of 8vg1 by Molmil
Cryo-EM structure of FoxA1 and GATA4 in complex with ALBN1 nucleosome
Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ...
Authors:Zhou, B.R, Bai, Y.
Deposit date:2023-12-22
Release date:2024-08-07
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.
Mol.Cell, 84, 2024
8VG0
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BU of 8vg0 by Molmil
Cryo-EM structure of GATA4 in complex with ALBN1 nucleosome
Descriptor: DNA (159-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Zhou, B.R, Bai, Y.
Deposit date:2023-12-22
Release date:2024-08-07
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.
Mol.Cell, 84, 2024
8CGC
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BU of 8cgc by Molmil
Structure of CSF1R in complex with a pyrollopyrimidine (compound 23)
Descriptor: (2S)-2-hydroxybutanedioic acid, GLYCEROL, Macrophage colony-stimulating factor 1 receptor, ...
Authors:Aarhus, T.I, Bjornstad, F, Wolowczyk, C, Larsen, K.U, Rognstad, L, Leithaug, T, Unger, A, Habenberger, P, Wolff, A, Bjorkoy, G, Pridans, C, Eickhoff, J, Klebl, B, Hoff, B.H, Sundby, E.
Deposit date:2023-02-03
Release date:2023-05-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.925 Å)
Cite:Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
J.Med.Chem., 66, 2023
9FQ0
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BU of 9fq0 by Molmil
Human NatA-NAC-MAP1 80S ribosome complex
Descriptor: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ...
Authors:Klein, M.A, Wild, K, Sinning, I.
Deposit date:2024-06-14
Release date:2024-07-03
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (4.67 Å)
Cite:Multi-protein assemblies orchestrate co-translational enzymatic processing on the human ribosome.
Nat Commun, 15, 2024
6UJA
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BU of 6uja by Molmil
Integrin alpha-v beta-8 in complex with pro-TGF-beta1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
Deposit date:2019-10-02
Release date:2020-02-05
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
3RJR
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BU of 3rjr by Molmil
Crystal Structure of pro-TGF beta 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1
Authors:Zhu, J.H, Shi, M.L, Springer, T.A.
Deposit date:2011-04-15
Release date:2011-06-15
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Latent TGF-Beta structure and activation
Nature, 474, 2011
5FFO
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BU of 5ffo by Molmil
Integrin alpha V beta 6 in complex with pro-TGF-beta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Dong, X, Zhao, B, Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
8Q68
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BU of 8q68 by Molmil
Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143
Descriptor: Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide
Authors:Ciesielski, F, Spieser, S.A.H, Marchand, A, Gwaltney, S.L.
Deposit date:2023-08-11
Release date:2023-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Mol.Cancer Ther., 23, 2024
6WXJ
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BU of 6wxj by Molmil
CSF1R signaling is a regulator of pathogenesis in progressive MS
Descriptor: 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine, Macrophage colony-stimulating factor 1 receptor
Authors:Liu, J.
Deposit date:2020-05-10
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:CSF1R signaling is a regulator of pathogenesis in progressive MS.
Cell Death Dis, 11, 2020
3AB3
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BU of 3ab3 by Molmil
Crystal structure of p115RhoGEF RGS domain in complex with G alpha 13
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, Guanine nucleotide-binding protein subunit alpha-13, ...
Authors:Kukimoto-Niino, M, Mishima, C, Shirouzu, M, Kozasa, T, Yokoyama, S.
Deposit date:2009-11-30
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
J.Biol.Chem., 286, 2011
8EVJ
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BU of 8evj by Molmil
CX3CR1 nucleosome bound PU.1 and C/EBPa
Descriptor: DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Guan, R, Bai, Y, Lian, T.
Deposit date:2022-10-20
Release date:2023-11-01
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha.
Nat.Struct.Mol.Biol., 31, 2024
8EVI
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BU of 8evi by Molmil
CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations
Descriptor: DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2022-10-20
Release date:2023-11-01
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha.
Nat.Struct.Mol.Biol., 31, 2024
8P2K
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BU of 8p2k by Molmil
Ternary complex of translating ribosome, NAC and METAP1
Descriptor: 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N.
Deposit date:2023-05-16
Release date:2023-07-19
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:NAC controls cotranslational N-terminal methionine excision in eukaryotes.
Science, 380, 2023
7Y1R
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BU of 7y1r by Molmil
Human L-TGF-beta1 in complex with the anchor protein LRRC33
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duan, Z, Zhang, Z.
Deposit date:2022-06-08
Release date:2022-08-31
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4.01 Å)
Cite:Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
6UMX
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BU of 6umx by Molmil
Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015
Descriptor: GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ...
Authors:Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J.
Deposit date:2019-10-10
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.
J.Biol.Chem., 295, 2020
7Y1T
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BU of 7y1t by Molmil
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duan, Z, Zhang, Z.
Deposit date:2022-06-08
Release date:2022-08-31
Last modified:2022-09-07
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
8VFZ
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BU of 8vfz by Molmil
Cryo-EM structure of FoxA1 in complex with ALBN1 nucleosome (class 2)
Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ...
Authors:Zhou, B.R, Bai, Y.
Deposit date:2023-12-22
Release date:2024-08-07
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.
Mol.Cell, 84, 2024
8VFY
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BU of 8vfy by Molmil
Cryo-EM structure of FoxA1 in complex with ALBN1 nucleosome (class 1)
Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ...
Authors:Zhou, B.R, Bai, Y.
Deposit date:2023-12-22
Release date:2024-08-07
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.
Mol.Cell, 84, 2024
4WUN
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BU of 4wun by Molmil
Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom
Descriptor: Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
Authors:Squire, C.J, Yosaatmadja, C.J.
Deposit date:2014-11-02
Release date:2014-11-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The 1.65 angstrom resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition.
Acta Crystallogr.,Sect.D, 71, 2015
3KZ1
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BU of 3kz1 by Molmil
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ...
Authors:Chen, Z, Sternweis, P.C, Sprang, S.R.
Deposit date:2009-12-07
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
J.Biol.Chem., 285, 2010
7UFG
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BU of 7ufg by Molmil
Cryo-EM structure of PAPP-A in complex with IGFBP5
Descriptor: Insulin-like growth factor-binding protein 5, Pappalysin-1, ZINC ION
Authors:Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D.
Deposit date:2022-03-22
Release date:2022-09-28
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
6E5G
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BU of 6e5g by Molmil
Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator
Descriptor: 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one, Transcriptional enhancer factor TEF-4
Authors:Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O.
Deposit date:2018-07-20
Release date:2019-01-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
Cell Chem Biol, 26, 2019

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数据于2024-11-06公开中

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