5FFO

Integrin alpha V beta 6 in complex with pro-TGF-beta

Summary for 5FFO

• Entry DOI: 10.2210/pdb5ffo/pdb
• Related: 5FFG
• Descriptor: Integrin alpha-V, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (14 entities in total)
• Functional Keywords: integrin, tgf-beta, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 368616.22

Authors

Dong, X.,Zhao, B.,Springer, T.A. (deposition date: 2015-12-18, release date: 2017-01-25, Last modification date: 2020-07-29)

• Primary citation: Dong, X.,Zhao, B.,Iacob, R.E.,Zhu, J.,Koksal, A.C.,Lu, C.,Engen, J.R.,Springer, T.A.; Force interacts with macromolecular structure in activation of TGF-beta.; Nature, 542:55-59, 2017; PubMed: 28117447; DOI: 10.1038/nature21035

Experimental method

X-RAY DIFFRACTION (3.49 Å)