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5FFO

Integrin alpha V beta 6 in complex with pro-TGF-beta

Functional Information from GO Data
ChainGOidnamespacecontents
A0007155biological_processcell adhesion
A0008305cellular_componentintegrin complex
C0001570biological_processvasculogenesis
C0001657biological_processureteric bud development
C0001666biological_processresponse to hypoxia
C0001763biological_processmorphogenesis of a branching structure
C0001837biological_processepithelial to mesenchymal transition
C0001843biological_processneural tube closure
C0002040biological_processsprouting angiogenesis
C0002062biological_processchondrocyte differentiation
C0002244biological_processhematopoietic progenitor cell differentiation
C0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
C0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
C0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
C0003179biological_processheart valve morphogenesis
C0003180biological_processaortic valve morphogenesis
C0005114molecular_functiontype II transforming growth factor beta receptor binding
C0005125molecular_functioncytokine activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005796cellular_componentGolgi lumen
C0005886cellular_componentplasma membrane
C0005902cellular_componentmicrovillus
C0006611biological_processprotein export from nucleus
C0006754biological_processATP biosynthetic process
C0006796biological_processphosphate-containing compound metabolic process
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007406biological_processnegative regulation of neuroblast proliferation
C0007435biological_processsalivary gland morphogenesis
C0007507biological_processheart development
C0007565biological_processfemale pregnancy
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009611biological_processresponse to wounding
C0009749biological_processresponse to glucose
C0009986cellular_componentcell surface
C0010332biological_processresponse to gamma radiation
C0010575biological_processpositive regulation of vascular endothelial growth factor production
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010716biological_processnegative regulation of extracellular matrix disassembly
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010742biological_processmacrophage derived foam cell differentiation
C0010763biological_processpositive regulation of fibroblast migration
C0010936biological_processnegative regulation of macrophage cytokine production
C0014003biological_processoligodendrocyte development
C0014008biological_processpositive regulation of microglia differentiation
C0016202biological_processregulation of striated muscle tissue development
C0019899molecular_functionenzyme binding
C0021915biological_processneural tube development
C0030141cellular_componentsecretory granule
C0030154biological_processcell differentiation
C0030214biological_processhyaluronan catabolic process
C0030308biological_processnegative regulation of cell growth
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0031012cellular_componentextracellular matrix
C0031093cellular_componentplatelet alpha granule lumen
C0031100biological_processanimal organ regeneration
C0031293biological_processmembrane protein intracellular domain proteolysis
C0031334biological_processpositive regulation of protein-containing complex assembly
C0031536biological_processpositive regulation of exit from mitosis
C0032355biological_processresponse to estradiol
C0032570biological_processresponse to progesterone
C0032667biological_processregulation of interleukin-23 production
C0032700biological_processnegative regulation of interleukin-17 production
C0032740biological_processpositive regulation of interleukin-17 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032801biological_processreceptor catabolic process
C0032930biological_processpositive regulation of superoxide anion generation
C0032967biological_processpositive regulation of collagen biosynthetic process
C0033280biological_processresponse to vitamin D
C0034616biological_processresponse to laminar fluid shear stress
C0034713molecular_functiontype I transforming growth factor beta receptor binding
C0034714molecular_functiontype III transforming growth factor beta receptor binding
C0035902biological_processresponse to immobilization stress
C0036120biological_processcellular response to platelet-derived growth factor stimulus
C0036446biological_processmyofibroblast differentiation
C0042127biological_processregulation of cell population proliferation
C0042306biological_processregulation of protein import into nucleus
C0042307biological_processpositive regulation of protein import into nucleus
C0042475biological_processodontogenesis of dentin-containing tooth
C0042552biological_processmyelination
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043117biological_processpositive regulation of vascular permeability
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043410biological_processpositive regulation of MAPK cascade
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0043537biological_processnegative regulation of blood vessel endothelial cell migration
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044877molecular_functionprotein-containing complex binding
C0045066biological_processregulatory T cell differentiation
C0045216biological_processcell-cell junction organization
C0045471biological_processresponse to ethanol
C0045591biological_processpositive regulation of regulatory T cell differentiation
C0045596biological_processnegative regulation of cell differentiation
C0045597biological_processpositive regulation of cell differentiation
C0045599biological_processnegative regulation of fat cell differentiation
C0045662biological_processnegative regulation of myoblast differentiation
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045786biological_processnegative regulation of cell cycle
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048298biological_processpositive regulation of isotype switching to IgA isotypes
C0048535biological_processlymph node development
C0048565biological_processdigestive tract development
C0048642biological_processnegative regulation of skeletal muscle tissue development
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0048839biological_processinner ear development
C0050679biological_processpositive regulation of epithelial cell proliferation
C0050680biological_processnegative regulation of epithelial cell proliferation
C0050714biological_processpositive regulation of protein secretion
C0050729biological_processpositive regulation of inflammatory response
C0050765biological_processnegative regulation of phagocytosis
C0050832biological_processdefense response to fungus
C0050921biological_processpositive regulation of chemotaxis
C0051130biological_processpositive regulation of cellular component organization
C0051240biological_processpositive regulation of multicellular organismal process
C0051247biological_processpositive regulation of protein metabolic process
C0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
C0051781biological_processpositive regulation of cell division
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055010biological_processventricular cardiac muscle tissue morphogenesis
C0060312biological_processregulation of blood vessel remodeling
C0060325biological_processface morphogenesis
C0060364biological_processfrontal suture morphogenesis
C0060391biological_processpositive regulation of SMAD protein signal transduction
C0070168biological_processnegative regulation of biomineral tissue development
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070723biological_processresponse to cholesterol
C0071260biological_processcellular response to mechanical stimulus
C0071333biological_processcellular response to glucose stimulus
C0071363biological_processcellular response to growth factor stimulus
C0071404biological_processcellular response to low-density lipoprotein particle stimulus
C0071456biological_processcellular response to hypoxia
C0071479biological_processcellular response to ionizing radiation
C0071549biological_processcellular response to dexamethasone stimulus
C0071560biological_processcellular response to transforming growth factor beta stimulus
C0071677biological_processpositive regulation of mononuclear cell migration
C0071895biological_processodontoblast differentiation
C0072562cellular_componentblood microparticle
C0085029biological_processextracellular matrix assembly
C0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0097421biological_processliver regeneration
C0098586biological_processcellular response to virus
C0099126cellular_componenttransforming growth factor beta complex
C0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
C1900126biological_processnegative regulation of hyaluronan biosynthetic process
C1900182biological_processpositive regulation of protein localization to nucleus
C1901203biological_processpositive regulation of extracellular matrix assembly
C1902074biological_processresponse to salt
C1902462biological_processpositive regulation of mesenchymal stem cell proliferation
C1902893biological_processregulation of miRNA transcription
C1902894biological_processnegative regulation of miRNA transcription
C1902895biological_processpositive regulation of miRNA transcription
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1904018biological_processpositive regulation of vasculature development
C1904894biological_processpositive regulation of receptor signaling pathway via STAT
C1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
C1905641biological_processcellular response to acetaldehyde
C1990314biological_processcellular response to insulin-like growth factor stimulus
C1990402biological_processembryonic liver development
C2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C2000353biological_processpositive regulation of endothelial cell apoptotic process
C2000636biological_processpositive regulation of primary miRNA processing
C2000727biological_processpositive regulation of cardiac muscle cell differentiation
D0001570biological_processvasculogenesis
D0001657biological_processureteric bud development
D0001666biological_processresponse to hypoxia
D0001763biological_processmorphogenesis of a branching structure
D0001837biological_processepithelial to mesenchymal transition
D0001843biological_processneural tube closure
D0002040biological_processsprouting angiogenesis
D0002062biological_processchondrocyte differentiation
D0002244biological_processhematopoietic progenitor cell differentiation
D0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
D0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
D0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0003179biological_processheart valve morphogenesis
D0003180biological_processaortic valve morphogenesis
D0005114molecular_functiontype II transforming growth factor beta receptor binding
D0005125molecular_functioncytokine activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005796cellular_componentGolgi lumen
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0006611biological_processprotein export from nucleus
D0006754biological_processATP biosynthetic process
D0006796biological_processphosphate-containing compound metabolic process
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007406biological_processnegative regulation of neuroblast proliferation
D0007435biological_processsalivary gland morphogenesis
D0007507biological_processheart development
D0007565biological_processfemale pregnancy
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0009611biological_processresponse to wounding
D0009749biological_processresponse to glucose
D0009986cellular_componentcell surface
D0010332biological_processresponse to gamma radiation
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010742biological_processmacrophage derived foam cell differentiation
D0010763biological_processpositive regulation of fibroblast migration
D0010936biological_processnegative regulation of macrophage cytokine production
D0014003biological_processoligodendrocyte development
D0014008biological_processpositive regulation of microglia differentiation
D0016202biological_processregulation of striated muscle tissue development
D0019899molecular_functionenzyme binding
D0021915biological_processneural tube development
D0030141cellular_componentsecretory granule
D0030154biological_processcell differentiation
D0030214biological_processhyaluronan catabolic process
D0030308biological_processnegative regulation of cell growth
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0031012cellular_componentextracellular matrix
D0031093cellular_componentplatelet alpha granule lumen
D0031100biological_processanimal organ regeneration
D0031293biological_processmembrane protein intracellular domain proteolysis
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031536biological_processpositive regulation of exit from mitosis
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0032667biological_processregulation of interleukin-23 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032801biological_processreceptor catabolic process
D0032930biological_processpositive regulation of superoxide anion generation
D0032967biological_processpositive regulation of collagen biosynthetic process
D0033280biological_processresponse to vitamin D
D0034616biological_processresponse to laminar fluid shear stress
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0034714molecular_functiontype III transforming growth factor beta receptor binding
D0035902biological_processresponse to immobilization stress
D0036120biological_processcellular response to platelet-derived growth factor stimulus
D0036446biological_processmyofibroblast differentiation
D0042127biological_processregulation of cell population proliferation
D0042306biological_processregulation of protein import into nucleus
D0042307biological_processpositive regulation of protein import into nucleus
D0042475biological_processodontogenesis of dentin-containing tooth
D0042552biological_processmyelination
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043117biological_processpositive regulation of vascular permeability
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043410biological_processpositive regulation of MAPK cascade
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0043537biological_processnegative regulation of blood vessel endothelial cell migration
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044877molecular_functionprotein-containing complex binding
D0045066biological_processregulatory T cell differentiation
D0045216biological_processcell-cell junction organization
D0045471biological_processresponse to ethanol
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045597biological_processpositive regulation of cell differentiation
D0045599biological_processnegative regulation of fat cell differentiation
D0045662biological_processnegative regulation of myoblast differentiation
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045786biological_processnegative regulation of cell cycle
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048298biological_processpositive regulation of isotype switching to IgA isotypes
D0048535biological_processlymph node development
D0048565biological_processdigestive tract development
D0048642biological_processnegative regulation of skeletal muscle tissue development
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0048839biological_processinner ear development
D0050679biological_processpositive regulation of epithelial cell proliferation
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050714biological_processpositive regulation of protein secretion
D0050729biological_processpositive regulation of inflammatory response
D0050765biological_processnegative regulation of phagocytosis
D0050832biological_processdefense response to fungus
D0050921biological_processpositive regulation of chemotaxis
D0051130biological_processpositive regulation of cellular component organization
D0051240biological_processpositive regulation of multicellular organismal process
D0051247biological_processpositive regulation of protein metabolic process
D0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060312biological_processregulation of blood vessel remodeling
D0060325biological_processface morphogenesis
D0060364biological_processfrontal suture morphogenesis
D0060391biological_processpositive regulation of SMAD protein signal transduction
D0070168biological_processnegative regulation of biomineral tissue development
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070723biological_processresponse to cholesterol
D0071260biological_processcellular response to mechanical stimulus
D0071333biological_processcellular response to glucose stimulus
D0071363biological_processcellular response to growth factor stimulus
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0071456biological_processcellular response to hypoxia
D0071479biological_processcellular response to ionizing radiation
D0071549biological_processcellular response to dexamethasone stimulus
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0071677biological_processpositive regulation of mononuclear cell migration
D0071895biological_processodontoblast differentiation
D0072562cellular_componentblood microparticle
D0085029biological_processextracellular matrix assembly
D0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0097191biological_processextrinsic apoptotic signaling pathway
D0097421biological_processliver regeneration
D0098586biological_processcellular response to virus
D0099126cellular_componenttransforming growth factor beta complex
D0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
D1900126biological_processnegative regulation of hyaluronan biosynthetic process
D1900182biological_processpositive regulation of protein localization to nucleus
D1901203biological_processpositive regulation of extracellular matrix assembly
D1902074biological_processresponse to salt
D1902462biological_processpositive regulation of mesenchymal stem cell proliferation
D1902893biological_processregulation of miRNA transcription
D1902894biological_processnegative regulation of miRNA transcription
D1902895biological_processpositive regulation of miRNA transcription
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1904018biological_processpositive regulation of vasculature development
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
D1905641biological_processcellular response to acetaldehyde
D1990314biological_processcellular response to insulin-like growth factor stimulus
D1990402biological_processembryonic liver development
D2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D2000353biological_processpositive regulation of endothelial cell apoptotic process
D2000636biological_processpositive regulation of primary miRNA processing
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
E0007155biological_processcell adhesion
E0008305cellular_componentintegrin complex
G0001570biological_processvasculogenesis
G0001657biological_processureteric bud development
G0001666biological_processresponse to hypoxia
G0001763biological_processmorphogenesis of a branching structure
G0001837biological_processepithelial to mesenchymal transition
G0001843biological_processneural tube closure
G0002040biological_processsprouting angiogenesis
G0002062biological_processchondrocyte differentiation
G0002244biological_processhematopoietic progenitor cell differentiation
G0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
G0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
G0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
G0003179biological_processheart valve morphogenesis
G0003180biological_processaortic valve morphogenesis
G0005114molecular_functiontype II transforming growth factor beta receptor binding
G0005125molecular_functioncytokine activity
G0005160molecular_functiontransforming growth factor beta receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005796cellular_componentGolgi lumen
G0005886cellular_componentplasma membrane
G0005902cellular_componentmicrovillus
G0006611biological_processprotein export from nucleus
G0006754biological_processATP biosynthetic process
G0006796biological_processphosphate-containing compound metabolic process
G0007179biological_processtransforming growth factor beta receptor signaling pathway
G0007406biological_processnegative regulation of neuroblast proliferation
G0007435biological_processsalivary gland morphogenesis
G0007507biological_processheart development
G0007565biological_processfemale pregnancy
G0008083molecular_functiongrowth factor activity
G0008284biological_processpositive regulation of cell population proliferation
G0008285biological_processnegative regulation of cell population proliferation
G0009410biological_processresponse to xenobiotic stimulus
G0009611biological_processresponse to wounding
G0009749biological_processresponse to glucose
G0009986cellular_componentcell surface
G0010332biological_processresponse to gamma radiation
G0010575biological_processpositive regulation of vascular endothelial growth factor production
G0010628biological_processpositive regulation of gene expression
G0010629biological_processnegative regulation of gene expression
G0010716biological_processnegative regulation of extracellular matrix disassembly
G0010718biological_processpositive regulation of epithelial to mesenchymal transition
G0010742biological_processmacrophage derived foam cell differentiation
G0010763biological_processpositive regulation of fibroblast migration
G0010936biological_processnegative regulation of macrophage cytokine production
G0014003biological_processoligodendrocyte development
G0014008biological_processpositive regulation of microglia differentiation
G0016202biological_processregulation of striated muscle tissue development
G0019899molecular_functionenzyme binding
G0021915biological_processneural tube development
G0030141cellular_componentsecretory granule
G0030154biological_processcell differentiation
G0030214biological_processhyaluronan catabolic process
G0030308biological_processnegative regulation of cell growth
G0030334biological_processregulation of cell migration
G0030335biological_processpositive regulation of cell migration
G0030424cellular_componentaxon
G0031012cellular_componentextracellular matrix
G0031093cellular_componentplatelet alpha granule lumen
G0031100biological_processanimal organ regeneration
G0031293biological_processmembrane protein intracellular domain proteolysis
G0031334biological_processpositive regulation of protein-containing complex assembly
G0031536biological_processpositive regulation of exit from mitosis
G0032355biological_processresponse to estradiol
G0032570biological_processresponse to progesterone
G0032667biological_processregulation of interleukin-23 production
G0032700biological_processnegative regulation of interleukin-17 production
G0032740biological_processpositive regulation of interleukin-17 production
G0032755biological_processpositive regulation of interleukin-6 production
G0032760biological_processpositive regulation of tumor necrosis factor production
G0032801biological_processreceptor catabolic process
G0032930biological_processpositive regulation of superoxide anion generation
G0032967biological_processpositive regulation of collagen biosynthetic process
G0033280biological_processresponse to vitamin D
G0034616biological_processresponse to laminar fluid shear stress
G0034713molecular_functiontype I transforming growth factor beta receptor binding
G0034714molecular_functiontype III transforming growth factor beta receptor binding
G0035902biological_processresponse to immobilization stress
G0036120biological_processcellular response to platelet-derived growth factor stimulus
G0036446biological_processmyofibroblast differentiation
G0042127biological_processregulation of cell population proliferation
G0042306biological_processregulation of protein import into nucleus
G0042307biological_processpositive regulation of protein import into nucleus
G0042475biological_processodontogenesis of dentin-containing tooth
G0042552biological_processmyelination
G0042802molecular_functionidentical protein binding
G0043025cellular_componentneuronal cell body
G0043065biological_processpositive regulation of apoptotic process
G0043117biological_processpositive regulation of vascular permeability
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0043410biological_processpositive regulation of MAPK cascade
G0043536biological_processpositive regulation of blood vessel endothelial cell migration
G0043537biological_processnegative regulation of blood vessel endothelial cell migration
G0043539molecular_functionprotein serine/threonine kinase activator activity
G0044877molecular_functionprotein-containing complex binding
G0045066biological_processregulatory T cell differentiation
G0045216biological_processcell-cell junction organization
G0045471biological_processresponse to ethanol
G0045591biological_processpositive regulation of regulatory T cell differentiation
G0045596biological_processnegative regulation of cell differentiation
G0045597biological_processpositive regulation of cell differentiation
G0045599biological_processnegative regulation of fat cell differentiation
G0045662biological_processnegative regulation of myoblast differentiation
G0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
G0045786biological_processnegative regulation of cell cycle
G0045892biological_processnegative regulation of DNA-templated transcription
G0045893biological_processpositive regulation of DNA-templated transcription
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0048298biological_processpositive regulation of isotype switching to IgA isotypes
G0048535biological_processlymph node development
G0048565biological_processdigestive tract development
G0048642biological_processnegative regulation of skeletal muscle tissue development
G0048661biological_processpositive regulation of smooth muscle cell proliferation
G0048839biological_processinner ear development
G0050679biological_processpositive regulation of epithelial cell proliferation
G0050680biological_processnegative regulation of epithelial cell proliferation
G0050714biological_processpositive regulation of protein secretion
G0050729biological_processpositive regulation of inflammatory response
G0050765biological_processnegative regulation of phagocytosis
G0050832biological_processdefense response to fungus
G0050921biological_processpositive regulation of chemotaxis
G0051130biological_processpositive regulation of cellular component organization
G0051240biological_processpositive regulation of multicellular organismal process
G0051247biological_processpositive regulation of protein metabolic process
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051781biological_processpositive regulation of cell division
G0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G0055010biological_processventricular cardiac muscle tissue morphogenesis
G0060312biological_processregulation of blood vessel remodeling
G0060325biological_processface morphogenesis
G0060364biological_processfrontal suture morphogenesis
G0060391biological_processpositive regulation of SMAD protein signal transduction
G0070168biological_processnegative regulation of biomineral tissue development
G0070374biological_processpositive regulation of ERK1 and ERK2 cascade
G0070723biological_processresponse to cholesterol
G0071260biological_processcellular response to mechanical stimulus
G0071333biological_processcellular response to glucose stimulus
G0071363biological_processcellular response to growth factor stimulus
G0071404biological_processcellular response to low-density lipoprotein particle stimulus
G0071456biological_processcellular response to hypoxia
G0071479biological_processcellular response to ionizing radiation
G0071549biological_processcellular response to dexamethasone stimulus
G0071560biological_processcellular response to transforming growth factor beta stimulus
G0071677biological_processpositive regulation of mononuclear cell migration
G0071895biological_processodontoblast differentiation
G0072562cellular_componentblood microparticle
G0085029biological_processextracellular matrix assembly
G0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
G0090263biological_processpositive regulation of canonical Wnt signaling pathway
G0097191biological_processextrinsic apoptotic signaling pathway
G0097421biological_processliver regeneration
G0098586biological_processcellular response to virus
G0099126cellular_componenttransforming growth factor beta complex
G0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
G1900126biological_processnegative regulation of hyaluronan biosynthetic process
G1900182biological_processpositive regulation of protein localization to nucleus
G1901203biological_processpositive regulation of extracellular matrix assembly
G1902074biological_processresponse to salt
G1902462biological_processpositive regulation of mesenchymal stem cell proliferation
G1902893biological_processregulation of miRNA transcription
G1902894biological_processnegative regulation of miRNA transcription
G1902895biological_processpositive regulation of miRNA transcription
G1903077biological_processnegative regulation of protein localization to plasma membrane
G1904018biological_processpositive regulation of vasculature development
G1904894biological_processpositive regulation of receptor signaling pathway via STAT
G1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
G1905641biological_processcellular response to acetaldehyde
G1990314biological_processcellular response to insulin-like growth factor stimulus
G1990402biological_processembryonic liver development
G2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
G2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
G2000353biological_processpositive regulation of endothelial cell apoptotic process
G2000636biological_processpositive regulation of primary miRNA processing
G2000727biological_processpositive regulation of cardiac muscle cell differentiation
H0001570biological_processvasculogenesis
H0001657biological_processureteric bud development
H0001666biological_processresponse to hypoxia
H0001763biological_processmorphogenesis of a branching structure
H0001837biological_processepithelial to mesenchymal transition
H0001843biological_processneural tube closure
H0002040biological_processsprouting angiogenesis
H0002062biological_processchondrocyte differentiation
H0002244biological_processhematopoietic progenitor cell differentiation
H0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
H0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
H0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
H0003179biological_processheart valve morphogenesis
H0003180biological_processaortic valve morphogenesis
H0005114molecular_functiontype II transforming growth factor beta receptor binding
H0005125molecular_functioncytokine activity
H0005160molecular_functiontransforming growth factor beta receptor binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005796cellular_componentGolgi lumen
H0005886cellular_componentplasma membrane
H0005902cellular_componentmicrovillus
H0006611biological_processprotein export from nucleus
H0006754biological_processATP biosynthetic process
H0006796biological_processphosphate-containing compound metabolic process
H0007179biological_processtransforming growth factor beta receptor signaling pathway
H0007406biological_processnegative regulation of neuroblast proliferation
H0007435biological_processsalivary gland morphogenesis
H0007507biological_processheart development
H0007565biological_processfemale pregnancy
H0008083molecular_functiongrowth factor activity
H0008284biological_processpositive regulation of cell population proliferation
H0008285biological_processnegative regulation of cell population proliferation
H0009410biological_processresponse to xenobiotic stimulus
H0009611biological_processresponse to wounding
H0009749biological_processresponse to glucose
H0009986cellular_componentcell surface
H0010332biological_processresponse to gamma radiation
H0010575biological_processpositive regulation of vascular endothelial growth factor production
H0010628biological_processpositive regulation of gene expression
H0010629biological_processnegative regulation of gene expression
H0010716biological_processnegative regulation of extracellular matrix disassembly
H0010718biological_processpositive regulation of epithelial to mesenchymal transition
H0010742biological_processmacrophage derived foam cell differentiation
H0010763biological_processpositive regulation of fibroblast migration
H0010936biological_processnegative regulation of macrophage cytokine production
H0014003biological_processoligodendrocyte development
H0014008biological_processpositive regulation of microglia differentiation
H0016202biological_processregulation of striated muscle tissue development
H0019899molecular_functionenzyme binding
H0021915biological_processneural tube development
H0030141cellular_componentsecretory granule
H0030154biological_processcell differentiation
H0030214biological_processhyaluronan catabolic process
H0030308biological_processnegative regulation of cell growth
H0030334biological_processregulation of cell migration
H0030335biological_processpositive regulation of cell migration
H0030424cellular_componentaxon
H0031012cellular_componentextracellular matrix
H0031093cellular_componentplatelet alpha granule lumen
H0031100biological_processanimal organ regeneration
H0031293biological_processmembrane protein intracellular domain proteolysis
H0031334biological_processpositive regulation of protein-containing complex assembly
H0031536biological_processpositive regulation of exit from mitosis
H0032355biological_processresponse to estradiol
H0032570biological_processresponse to progesterone
H0032667biological_processregulation of interleukin-23 production
H0032700biological_processnegative regulation of interleukin-17 production
H0032740biological_processpositive regulation of interleukin-17 production
H0032755biological_processpositive regulation of interleukin-6 production
H0032760biological_processpositive regulation of tumor necrosis factor production
H0032801biological_processreceptor catabolic process
H0032930biological_processpositive regulation of superoxide anion generation
H0032967biological_processpositive regulation of collagen biosynthetic process
H0033280biological_processresponse to vitamin D
H0034616biological_processresponse to laminar fluid shear stress
H0034713molecular_functiontype I transforming growth factor beta receptor binding
H0034714molecular_functiontype III transforming growth factor beta receptor binding
H0035902biological_processresponse to immobilization stress
H0036120biological_processcellular response to platelet-derived growth factor stimulus
H0036446biological_processmyofibroblast differentiation
H0042127biological_processregulation of cell population proliferation
H0042306biological_processregulation of protein import into nucleus
H0042307biological_processpositive regulation of protein import into nucleus
H0042475biological_processodontogenesis of dentin-containing tooth
H0042552biological_processmyelination
H0042802molecular_functionidentical protein binding
H0043025cellular_componentneuronal cell body
H0043065biological_processpositive regulation of apoptotic process
H0043117biological_processpositive regulation of vascular permeability
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043410biological_processpositive regulation of MAPK cascade
H0043536biological_processpositive regulation of blood vessel endothelial cell migration
H0043537biological_processnegative regulation of blood vessel endothelial cell migration
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044877molecular_functionprotein-containing complex binding
H0045066biological_processregulatory T cell differentiation
H0045216biological_processcell-cell junction organization
H0045471biological_processresponse to ethanol
H0045591biological_processpositive regulation of regulatory T cell differentiation
H0045596biological_processnegative regulation of cell differentiation
H0045597biological_processpositive regulation of cell differentiation
H0045599biological_processnegative regulation of fat cell differentiation
H0045662biological_processnegative regulation of myoblast differentiation
H0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
H0045786biological_processnegative regulation of cell cycle
H0045892biological_processnegative regulation of DNA-templated transcription
H0045893biological_processpositive regulation of DNA-templated transcription
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0048298biological_processpositive regulation of isotype switching to IgA isotypes
H0048535biological_processlymph node development
H0048565biological_processdigestive tract development
H0048642biological_processnegative regulation of skeletal muscle tissue development
H0048661biological_processpositive regulation of smooth muscle cell proliferation
H0048839biological_processinner ear development
H0050679biological_processpositive regulation of epithelial cell proliferation
H0050680biological_processnegative regulation of epithelial cell proliferation
H0050714biological_processpositive regulation of protein secretion
H0050729biological_processpositive regulation of inflammatory response
H0050765biological_processnegative regulation of phagocytosis
H0050832biological_processdefense response to fungus
H0050921biological_processpositive regulation of chemotaxis
H0051130biological_processpositive regulation of cellular component organization
H0051240biological_processpositive regulation of multicellular organismal process
H0051247biological_processpositive regulation of protein metabolic process
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051781biological_processpositive regulation of cell division
H0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
H0055010biological_processventricular cardiac muscle tissue morphogenesis
H0060312biological_processregulation of blood vessel remodeling
H0060325biological_processface morphogenesis
H0060364biological_processfrontal suture morphogenesis
H0060391biological_processpositive regulation of SMAD protein signal transduction
H0070168biological_processnegative regulation of biomineral tissue development
H0070374biological_processpositive regulation of ERK1 and ERK2 cascade
H0070723biological_processresponse to cholesterol
H0071260biological_processcellular response to mechanical stimulus
H0071333biological_processcellular response to glucose stimulus
H0071363biological_processcellular response to growth factor stimulus
H0071404biological_processcellular response to low-density lipoprotein particle stimulus
H0071456biological_processcellular response to hypoxia
H0071479biological_processcellular response to ionizing radiation
H0071549biological_processcellular response to dexamethasone stimulus
H0071560biological_processcellular response to transforming growth factor beta stimulus
H0071677biological_processpositive regulation of mononuclear cell migration
H0071895biological_processodontoblast differentiation
H0072562cellular_componentblood microparticle
H0085029biological_processextracellular matrix assembly
H0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
H0090263biological_processpositive regulation of canonical Wnt signaling pathway
H0097191biological_processextrinsic apoptotic signaling pathway
H0097421biological_processliver regeneration
H0098586biological_processcellular response to virus
H0099126cellular_componenttransforming growth factor beta complex
H0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
H1900126biological_processnegative regulation of hyaluronan biosynthetic process
H1900182biological_processpositive regulation of protein localization to nucleus
H1901203biological_processpositive regulation of extracellular matrix assembly
H1902074biological_processresponse to salt
H1902462biological_processpositive regulation of mesenchymal stem cell proliferation
H1902893biological_processregulation of miRNA transcription
H1902894biological_processnegative regulation of miRNA transcription
H1902895biological_processpositive regulation of miRNA transcription
H1903077biological_processnegative regulation of protein localization to plasma membrane
H1904018biological_processpositive regulation of vasculature development
H1904894biological_processpositive regulation of receptor signaling pathway via STAT
H1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
H1905641biological_processcellular response to acetaldehyde
H1990314biological_processcellular response to insulin-like growth factor stimulus
H1990402biological_processembryonic liver development
H2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
H2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
H2000353biological_processpositive regulation of endothelial cell apoptotic process
H2000636biological_processpositive regulation of primary miRNA processing
H2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
CILE282-CYS297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues122
DetailsRepeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues104
DetailsRepeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues108
DetailsRepeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues130
DetailsRepeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues114
DetailsRepeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FFG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues66
DetailsRepeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues480
DetailsDomain: {"description":"VWFA","evidences":[{"source":"UniProtKB","id":"P05106","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"description":"in MIDAS binding site","evidences":[{"source":"UniProtKB","id":"P05106","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues8
DetailsBinding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues2
DetailsBinding site: {"description":"in ADMIDAS binding site and liganded-open conformation","evidences":[{"source":"UniProtKB","id":"P05106","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25383667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues8
DetailsMotif: {"description":"Cell attachment site","evidences":[{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FFO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues26
DetailsRegion: {"description":"Bowtie tail","evidences":[{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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