5FFO
Integrin alpha V beta 6 in complex with pro-TGF-beta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Integrin alpha-V | polymer | 601 | 65982.9 | 2 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) | Homo sapiens (Human) | Vitronectin receptor subunit alpha |
| 2 | B, F (B, F) | Integrin beta-6 | polymer | 257 | 28851.7 | 2 | UniProt (P18564) Pfam (PF00362) | Homo sapiens (Human) | |
| 3 | C, D, G, H (C, D, G, H) | Transforming growth factor beta-1 | polymer | 363 | 41489.4 | 4 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (Human) | TGF-beta-1 |
| 4 | I, P (I, P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | J, Q (J, Q) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G34442SS) | |||
| 6 | K, R (K, R) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G55220VL) | |||
| 7 | L, S (L, S) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 8 | M, T (M, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 9 | N, O, U (N, O, U) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 10 | V (V) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 11 | FA, GA, HA, IA, W... (E, A) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 12 | AA, EA, JA, NA (A, B, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 13 | BA, CA, DA, KA, LA... (B, F) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 14 | OA, PA (B, F) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 598 (UniProt: P06756)
B, F: 111 - 361 (UniProt: P18564)
C, D, G, H: 5 - 361 (UniProt: P01137)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | insertion |
| Cys 401 | Met 430 | conflict |
| Thr 597 | Cys 626 | conflict |
| Gly 599 | - | expression tag |
| Leu 600 | - | expression tag |
| Glu 601 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 270 | Ile 287 | conflict |
| His 362 | - | expression tag |
| His 363 | - | expression tag |
| His 364 | - | expression tag |
| His 365 | - | expression tag |
| His 366 | - | expression tag |
| His 367 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Thr 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gln 107 | Asn 136 | conflict |
| Gln 147 | Asn 176 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 355626.7 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 11454.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1535.1 | |
| All* | Total formula weight | 368616.2 |
