3AB3

Crystal structure of p115RhoGEF RGS domain in complex with G alpha 13

Summary for 3AB3

• Entry DOI: 10.2210/pdb3ab3/pdb
• Related: 1ZCB
• Descriptor: Guanine nucleotide-binding protein G(k) subunit alpha, Guanine nucleotide-binding protein subunit alpha-13, Rho guanine nucleotide exchange factor 1, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: signal transduction, protein complex, gtp-binding, membrane, transducer, lipoprotein, nucleotide-binding, palmitate, phosphoprotein, gtpase activation, guanine-nucleotide releasing factor, signaling protein-membrane protein complex, signaling protein/membrane protein
• Biological source: Mus musculus (mouse); More
• Cellular location: Membrane ; Lipid-anchor : P27601; Cytoplasm : Q92888
• Total number of polymer chains: 4
• Total formula weight: 141164.68

Authors

Kukimoto-Niino, M.,Mishima, C.,Shirouzu, M.,Kozasa, T.,Yokoyama, S. (deposition date: 2009-11-30, release date: 2010-12-29, Last modification date: 2023-11-01)

• Primary citation: Hajicek, N.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Chow, C.R.,Shirouzu, M.,Terada, T.,Patel, M.,Yokoyama, S.,Kozasa, T.; Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.; J.Biol.Chem., 286:20625-20636, 2011; PubMed: 21507947; DOI: 10.1074/jbc.M110.201392

Experimental method

X-RAY DIFFRACTION (2.4 Å)