3AB3
Crystal structure of p115RhoGEF RGS domain in complex with G alpha 13
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Guanine nucleotide-binding protein G(k) subunit alpha, Guanine nucleotide-binding protein subunit alpha-13 | polymer | 362 | 42363.4 | 2 | UniProt (Q9DC51) UniProt (P27601) Pfam (PF00503) In PDB | Mus musculus (mouse) | G-protein subunit alpha-13, G alpha-13 |
2 | B, D | Rho guanine nucleotide exchange factor 1 | polymer | 246 | 27648.4 | 2 | UniProt (Q92888) Pfam (PF09128) In PDB | Homo sapiens (human) | 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub1.5 |
3 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
5 | A, C | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
6 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, C: 16 - 43 (UniProt: Q9DC51)
A, C: 47 - 377 (UniProt: P27601)
B, D: 1 - 233 (UniProt: Q92888)
PDB | External Database | Details |
---|---|---|
Arg 44 | - | linker |
Ser 45 | - | linker |
Ala 46 | - | linker |
B, D: 1 - 233 (UniProt: Q92888)
PDB | External Database | Details |
---|---|---|
Gly -12 | - | expression tag |
Ala -11 | - | expression tag |
Met -10 | - | expression tag |
Gly -9 | - | expression tag |
Ile -8 | - | expression tag |
Gln -7 | - | expression tag |
Cys -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Ile -3 | - | expression tag |
Leu -2 | - | expression tag |
Val -1 | - | expression tag |
Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 140023.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1141.0 | |
All* | Total formula weight | 141164.7 |