8Q68

Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143

Summary for 8Q68

• Entry DOI: 10.2210/pdb8q68/pdb
• Descriptor: Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide (3 entities in total)
• Functional Keywords: irreversible covalent inhibitor, mesothelioma tumor regression, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 55945.49

Authors

Ciesielski, F.,Spieser, S.A.H.,Marchand, A.,Gwaltney, S.L. (deposition date: 2023-08-11, release date: 2023-10-04, Last modification date: 2024-01-17)

• Primary citation: Hillen, H.,Candi, A.,Vanderhoydonck, B.,Kowalczyk, W.,Sansores-Garcia, L.,Kesikiadou, E.C.,Van Huffel, L.,Spiessens, L.,Nijs, M.,Soons, E.,Haeck, W.,Klaassen, H.,Smets, W.,Spieser, S.A.,Marchand, A.,Chaltin, P.,Ciesielski, F.,Debaene, F.,Chen, L.,Kamal, A.,Gwaltney, S.L.,Versele, M.,Halder, G.A.; A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.; Mol.Cancer Ther., 23:3-13, 2024; PubMed: 37748190; DOI: 10.1158/1535-7163.MCT-22-0681

Experimental method

X-RAY DIFFRACTION (1.58 Å)