7UFG

Cryo-EM structure of PAPP-A in complex with IGFBP5

Summary for 7UFG

Entry DOI	10.2210/pdb7ufg/pdb
EMDB information	26475
Descriptor	Pappalysin-1, Insulin-like growth factor-binding protein 5, ZINC ION (3 entities in total)
Functional Keywords	metalloprotease, metal-binding, hydrolase, hydrolase-hormone complex, hydrolase/hormone
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	414566.78
Authors	Judge, R.A.,Jain, R.,Hao, Q.,Ouch, C.,Sridar, J.,Smith, C.L.,Wang, J.C.K.,Eaton, D. (deposition date: 2022-03-22, release date: 2022-09-28)
Primary citation	Judge, R.A.,Sridar, J.,Tunyasunvunakool, K.,Jain, R.,Wang, J.C.K.,Ouch, C.,Xu, J.,Mafi, A.,Nile, A.H.,Remarcik, C.,Smith, C.L.,Ghosh, C.,Xu, C.,Stoll, V.,Jumper, J.,Singh, A.H.,Eaton, D.,Hao, Q. Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition Nat Commun, 13:5500-, 2022 Cited by PubMed: 36127359 DOI: 10.1038/s41467-022-33175-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.28 Å)

Structure validation