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7UFG

Cryo-EM structure of PAPP-A in complex with IGFBP5

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007166biological_processcell surface receptor signaling pathway
A0007565biological_processfemale pregnancy
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0030163biological_processprotein catabolic process
A0032354biological_processresponse to follicle-stimulating hormone
A0046872molecular_functionmetal ion binding
A0071548biological_processresponse to dexamethasone
B0004175molecular_functionendopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0007166biological_processcell surface receptor signaling pathway
B0007565biological_processfemale pregnancy
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0030163biological_processprotein catabolic process
B0032354biological_processresponse to follicle-stimulating hormone
B0046872molecular_functionmetal ion binding
B0071548biological_processresponse to dexamethasone
C0001558biological_processregulation of cell growth
C0001649biological_processosteoblast differentiation
C0001968molecular_functionfibronectin binding
C0005515molecular_functionprotein binding
C0005520molecular_functioninsulin-like growth factor binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005788cellular_componentendoplasmic reticulum lumen
C0007165biological_processsignal transduction
C0007565biological_processfemale pregnancy
C0014070biological_processresponse to organic cyclic compound
C0014912biological_processnegative regulation of smooth muscle cell migration
C0016942cellular_componentinsulin-like growth factor binding protein complex
C0017148biological_processnegative regulation of translation
C0019838molecular_functiongrowth factor binding
C0030336biological_processnegative regulation of cell migration
C0031069biological_processhair follicle morphogenesis
C0031994molecular_functioninsulin-like growth factor I binding
C0031995molecular_functioninsulin-like growth factor II binding
C0035556biological_processintracellular signal transduction
C0040008biological_processregulation of growth
C0042567cellular_componentinsulin-like growth factor ternary complex
C0042593biological_processglucose homeostasis
C0043567biological_processregulation of insulin-like growth factor receptor signaling pathway
C0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
C0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
C0044342biological_processtype B pancreatic cell proliferation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045926biological_processnegative regulation of growth
C0048009biological_processinsulin-like growth factor receptor signaling pathway
C0048286biological_processlung alveolus development
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0051146biological_processstriated muscle cell differentiation
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060056biological_processmammary gland involution
C0060416biological_processresponse to growth hormone
C0071320biological_processcellular response to cAMP
C0071407biological_processcellular response to organic cyclic compound
C1901862biological_processnegative regulation of muscle tissue development
C1904205biological_processnegative regulation of skeletal muscle hypertrophy
C1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
C1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
D0001558biological_processregulation of cell growth
D0001649biological_processosteoblast differentiation
D0001968molecular_functionfibronectin binding
D0005515molecular_functionprotein binding
D0005520molecular_functioninsulin-like growth factor binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0007165biological_processsignal transduction
D0007565biological_processfemale pregnancy
D0014070biological_processresponse to organic cyclic compound
D0014912biological_processnegative regulation of smooth muscle cell migration
D0016942cellular_componentinsulin-like growth factor binding protein complex
D0017148biological_processnegative regulation of translation
D0019838molecular_functiongrowth factor binding
D0030336biological_processnegative regulation of cell migration
D0031069biological_processhair follicle morphogenesis
D0031994molecular_functioninsulin-like growth factor I binding
D0031995molecular_functioninsulin-like growth factor II binding
D0035556biological_processintracellular signal transduction
D0040008biological_processregulation of growth
D0042567cellular_componentinsulin-like growth factor ternary complex
D0042593biological_processglucose homeostasis
D0043567biological_processregulation of insulin-like growth factor receptor signaling pathway
D0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
D0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
D0044342biological_processtype B pancreatic cell proliferation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045926biological_processnegative regulation of growth
D0048009biological_processinsulin-like growth factor receptor signaling pathway
D0048286biological_processlung alveolus development
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0051146biological_processstriated muscle cell differentiation
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060056biological_processmammary gland involution
D0060416biological_processresponse to growth hormone
D0071320biological_processcellular response to cAMP
D0071407biological_processcellular response to organic cyclic compound
D1901862biological_processnegative regulation of muscle tissue development
D1904205biological_processnegative regulation of skeletal muscle hypertrophy
D1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
D1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
Functional Information from PROSITE/UniProt
site_idPS00222
Number of Residues16
DetailsIGFBP_N_1 Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. GCGCCmtCAlaegqsC
ChainResidueDetails
DGLY32-CYS47

site_idPS00484
Number of Residues34
DetailsTHYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YlpnCdrk.GfYkrkQckpsrgrkrgicWCVdky.G
ChainResidueDetails
DTYR195-GLY228

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
DSER96
CSER96

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: O-linked (HexNAc...) threonine => ECO:0000269|PubMed:9883900
ChainResidueDetails
DTHR152
CTHR152
AHIS492
BHIS482
BHIS486
BHIS492

site_idSWS_FT_FI3
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN310
AASN745
AASN1142
AASN1385
BASN310
BASN745
BASN1142
BASN1385

site_idSWS_FT_FI4
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12421832
ChainResidueDetails
AASN322
AASN1439
BASN322
BASN349
BASN400
BASN521
BASN539
BASN645
BASN946
BASN1146
BASN1243
AASN349
BASN1439
AASN400
AASN521
AASN539
AASN645
AASN946
AASN1146
AASN1243

223166

PDB entries from 2024-07-31

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