7UFG
Cryo-EM structure of PAPP-A in complex with IGFBP5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pappalysin-1 | polymer | 1581 | 176341.7 | 2 | UniProt (Q13219) Pfam (PF13385) Pfam (PF05572) Pfam (PF25900) Pfam (PF00084) | Homo sapiens (human) | Insulin-like growth factor-dependent IGF-binding protein 4 protease,IGF-dependent IGFBP-4 protease,IGFBP-4ase,Pregnancy-associated plasma protein A,PAPP-A |
| 2 | C, D (D, C) | Insulin-like growth factor-binding protein 5 | polymer | 272 | 30876.3 | 2 | UniProt (P24593) Pfam (PF00219) Pfam (PF00086) | Homo sapiens (human) | IBP-5,IGF-binding protein 5,IGFBP-5 |
| 3 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 1547 (UniProt: Q13219)
D, C: 1 - 252 (UniProt: P24593)
| PDB | External Database | Details |
|---|---|---|
| Ala 483 | Glu 563 | engineered mutation |
| Tyr 1144 | Ser 1224 | engineered mutation |
| Ser 1548 | - | expression tag |
| Gly 1549 | - | expression tag |
| Pro 1550 | - | expression tag |
| Thr 1551 | - | expression tag |
| Arg 1552 | - | expression tag |
| Thr 1553 | - | expression tag |
| Arg 1554 | - | expression tag |
| Pro 1555 | - | expression tag |
| Leu 1556 | - | expression tag |
| Glu 1557 | - | expression tag |
| Gln 1558 | - | expression tag |
| Lys 1559 | - | expression tag |
| Leu 1560 | - | expression tag |
| Ile 1561 | - | expression tag |
| Ser 1562 | - | expression tag |
| Glu 1563 | - | expression tag |
| Glu 1564 | - | expression tag |
| Asp 1565 | - | expression tag |
| Leu 1566 | - | expression tag |
| Ala 1567 | - | expression tag |
| Ala 1568 | - | expression tag |
| Asn 1569 | - | expression tag |
| Asp 1570 | - | expression tag |
| Ile 1571 | - | expression tag |
| Leu 1572 | - | expression tag |
| Asp 1573 | - | expression tag |
| Tyr 1574 | - | expression tag |
| Lys 1575 | - | expression tag |
| Asp 1576 | - | expression tag |
| Asp 1577 | - | expression tag |
| Asp 1578 | - | expression tag |
| Asp 1579 | - | expression tag |
| Lys 1580 | - | expression tag |
| Val 1581 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ala 253 | - | expression tag |
| Ala 254 | - | expression tag |
| Ala 255 | - | expression tag |
| Asp 256 | - | expression tag |
| Tyr 257 | - | expression tag |
| Lys 258 | - | expression tag |
| Asp 259 | - | expression tag |
| Asp 260 | - | expression tag |
| Asp 261 | - | expression tag |
| Asp 262 | - | expression tag |
| Lys 263 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 414436.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 414566.8 |
