6E5G

Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator

Summary for 6E5G

Entry DOI	10.2210/pdb6e5g/pdb
Descriptor	Transcriptional enhancer factor TEF-4, 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one (3 entities in total)
Functional Keywords	inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	53987.01
Authors	Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. (deposition date: 2018-07-20, release date: 2019-01-09, Last modification date: 2023-10-11)
Primary citation	Bum-Erdene, K.,Zhou, D.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Si, Y.,Xu, D.,Shannon, H.E.,Bailey, B.J.,Corson, T.W.,Pollok, K.E.,Wells, C.D.,Meroueh, S.O. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol, 26:378-, 2019 Cited by PubMed: 30581134 DOI: 10.1016/j.chembiol.2018.11.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation