6E5G
Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | Transcriptional enhancer factor TEF-4 | polymer | 235 | 26714.2 | 2 | UniProt (Q15562) Pfam (PF17725) In PDB | Homo sapiens (Human) | TEA domain family member 2, TEAD-2 |
| 2 | B, A | 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one | non-polymer | 279.3 | 2 | Chemie (HUY) | |||
| 3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
B, A: 217 - 447 (UniProt: Q15562)
| PDB | External Database | Details |
|---|---|---|
| Gly 213 | - | expression tag |
| Ser 214 | - | expression tag |
| His 215 | - | expression tag |
| Met 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53428.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 558.5 | |
| All* | Total formula weight | 53987.0 |
