4WUN

Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom

Summary for 4WUN

Entry DOI	10.2210/pdb4wun/pdb
Descriptor	Fibroblast growth factor receptor 1, N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide (3 entities in total)
Functional Keywords	transferase; transferase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	71634.37
Authors	Squire, C.J.,Yosaatmadja, C.J. (deposition date: 2014-11-02, release date: 2014-11-19, Last modification date: 2023-09-27)
Primary citation	Yosaatmadja, Y.,Patterson, A.V.,Smaill, J.B.,Squire, C.J. The 1.65 angstrom resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition. Acta Crystallogr.,Sect.D, 71:525-533, 2015 Cited by PubMed: 25760602 DOI: 10.1107/S1399004714027539 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation