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4WUN

Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005007molecular_functionfibroblast growth factor receptor activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005007molecular_functionfibroblast growth factor receptor activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue 66T A 801
ChainResidue
ALEU484
ATYR563
AALA564
ASER565
AGLY567
AGLU571
ALEU630
AALA640
AASP641
AGLY485
AALA512
ALYS514
AGLU531
AMET535
AVAL559
AVAL561
AGLU562

site_idAC2
Number of Residues14
Detailsbinding site for residue 66T B 801
ChainResidue
BGLY485
BALA512
BLYS514
BGLU531
BVAL561
BGLU562
BTYR563
BALA564
BSER565
BGLY567
BLEU630
BASP641
BPHE642
BHOH989

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK
ChainResidueDetails
ALEU484-LYS514

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
ChainResidueDetails
ACYS619-VAL631

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
ChainResidueDetails
AGLU592
BGLU592

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING:
ChainResidueDetails
APRO483
BGLY610
AGLU531
AMET537
ASER596
AGLY610
BPRO483
BGLU531
BMET537
BSER596

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Mediates interaction with PLCG1 and SHB
ChainResidueDetails
AASP735
BASP735

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
ATHR552
AASP554
BTHR552
BASP554

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701
ChainResidueDetails
AARG622
AASP623
BARG622
BASP623

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
ASER699
BSER699

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19665973
ChainResidueDetails
AASP735
BASP735

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PDB entries from 2024-10-30

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