4WUN
Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 311 | 35353.6 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, D (A, B) | N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide | non-polymer | 463.6 | 2 | Chemie (66T) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 455 | - | expression tag |
| Ala 456 | - | expression tag |
| Met 457 | - | expression tag |
| Ser 458 | - | expression tag |
| Ala 488 | Cys 519 | conflict |
| Ser 584 | Cys 615 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70707.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 927.1 | |
| All* | Total formula weight | 71634.4 |
