5E0V
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5E0T
| Human PCNA mutant - S228I | Descriptor: | Proliferating cell nuclear antigen | Authors: | Duffy, C.M, Hilbert, B.J, Kelch, B.A. | Deposit date: | 2015-09-29 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6653 Å) | Cite: | A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428, 2016
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1W7H
| p38 Kinase crystal structure in complex with small molecule inhibitor | Descriptor: | 3-(BENZYLOXY)PYRIDIN-2-AMINE, MITOGEN-ACTIVATED PROTEIN KINASE 14 | Authors: | Jhoti, H, Gill, A, Cleasby, A, Devine, L. | Deposit date: | 2004-09-02 | Release date: | 2005-02-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.214 Å) | Cite: | Fragment-Based Lead Discovery Using X-Ray Crystallography J.Med.Chem., 48, 2005
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6R3S
| CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 | Descriptor: | 1,2-ETHANEDIOL, 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide, Cyclin-C, ... | Authors: | Boettcher, J. | Deposit date: | 2019-03-21 | Release date: | 2020-04-08 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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7K1B
| CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex II) | Descriptor: | DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*AP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit | Authors: | Chen, X, Gellert, M, Yang, W. | Deposit date: | 2020-09-07 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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5E0U
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8UW3
| Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state | Descriptor: | Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ... | Authors: | Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E. | Deposit date: | 2023-11-06 | Release date: | 2023-12-20 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Template and target-site recognition by human LINE-1 in retrotransposition. Nature, 626, 2024
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8AT6
| Cryo-EM structure of yeast Elp456 subcomplex | Descriptor: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-22 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8ASV
| Cryo-EM structure of yeast Elongator complex | Descriptor: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-21 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.35 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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7M0D
| Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound complementary DSB substrate and incoming dUMPNPP | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2021-03-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
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4JGH
| Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5 | Descriptor: | Cullin-5, Suppressor of cytokine signaling 2, Transcription elongation factor B polypeptide 1, ... | Authors: | Kim, Y.K, Kwak, M.J, Ku, B, Suh, H.Y, Joo, K, Lee, J, Jung, J.U, Oh, B.H. | Deposit date: | 2013-03-01 | Release date: | 2013-08-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Acta Crystallogr.,Sect.D, 69, 2013
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8JRV
| Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | Descriptor: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ... | Authors: | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
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3HUB
| Human p38 MAP Kinase in Complex with Scios-469 | Descriptor: | 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Rauh, D. | Deposit date: | 2009-06-13 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
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3HUC
| Human p38 MAP Kinase in Complex with RL40 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, ... | Authors: | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | Deposit date: | 2009-06-13 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
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3ZNG
| Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC | Descriptor: | 1,2-ETHANEDIOL, ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... | Authors: | Thomas, J, Van Molle, I, Ciulli, A. | Deposit date: | 2013-02-14 | Release date: | 2013-12-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Multimeric Complexes Among Ankyrin-Repeat and Socs-Box Protein 9 (Asb9), Elonginbc, and Cullin 5: Insights Into the Structure and Assembly of Ecs-Type Cullin-Ring E3 Ubiquitin Ligases. Biochemistry, 52, 2013
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4LN7
| 5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease | Descriptor: | 1,2-ETHANEDIOL, 5,6-bis(4-fluorophenyl)pyridine-2,3-diol, MAGNESIUM ION, ... | Authors: | Bauman, J.D, Patel, D, Das, K, Arnold, E. | Deposit date: | 2013-07-11 | Release date: | 2013-09-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
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3RGF
| Crystal Structure of human CDK8/CycC | Descriptor: | 1,2-ETHANEDIOL, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Cyclin-C, ... | Authors: | Schneider, E.V, Boettcher, J, Blaesse, M, Huber, R, Maskos, K. | Deposit date: | 2011-04-08 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. J.Mol.Biol., 412, 2011
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6WK2
| SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine | Descriptor: | 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ... | Authors: | Dai, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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1WLJ
| human ISG20 | Descriptor: | ACETATE ION, MANGANESE (II) ION, URIDINE-5'-MONOPHOSPHATE, ... | Authors: | Horio, T, Murai, M, Inoue, T, Hamasaki, T, Tanaka, T, Ohgi, T. | Deposit date: | 2004-06-28 | Release date: | 2004-12-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease Febs Lett., 577, 2004
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5VFU
| Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | Deposit date: | 2017-04-09 | Release date: | 2018-07-18 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
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6WK1
| SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Actin, ... | Authors: | Dai, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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6KTO
| Crystal structure of human SHLD3-C-REV7-O-REV7-SHLD2 complex | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 2, Shieldin complex subunit 3 | Authors: | Liang, L, Yin, Y. | Deposit date: | 2019-08-28 | Release date: | 2020-04-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.4497633 Å) | Cite: | Molecular basis for assembly of the shieldin complex and its implications for NHEJ. Nat Commun, 11, 2020
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2C9O
| 3D Structure of the human RuvB-like helicase RuvBL1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RUVB-LIKE 1 | Authors: | Matias, P.M, Gorynia, S, Donner, P, Carrondo, M.A. | Deposit date: | 2005-12-14 | Release date: | 2006-10-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the human AAA+ protein RuvBL1. J. Biol. Chem., 281, 2006
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3TG4
| Structure of SMYD2 in complex with SAM | Descriptor: | GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... | Authors: | Zhao, K, Wang, L. | Deposit date: | 2011-08-17 | Release date: | 2011-08-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011
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4M4Q
| 6-(4-fluorophenyl)-3-hydroxy-5-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl] -1,2-dihydropyridin-2-one bound to influenza 2009 H1N1 endonuclease | Descriptor: | 6-(4-fluorophenyl)-5-[4-(1H-tetrazol-5-yl)phenyl]pyridine-2,3-diol, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Bauman, J.D, Patel, D, Das, K, Arnold, E. | Deposit date: | 2013-08-07 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
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