8UW3

Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state

Summary for 8UW3

Entry DOI	10.2210/pdb8uw3/pdb
EMDB information	42637
Descriptor	LINE-1 retrotransposable element ORF2 protein, Template RNA, Complementary DNA, ... (4 entities in total)
Functional Keywords	line-1, retrotransposon, reverse transcriptase, retroelement, rna binding protein, rna, rna binding protein-rna-dna complex, rna binding protein/rna/dna
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	177690.60
Authors	Thawani, A.,Florez Ariza, A.J.,Collins, K.,Nogales, E. (deposition date: 2023-11-06, release date: 2023-12-20, Last modification date: 2024-02-14)
Primary citation	Thawani, A.,Ariza, A.J.F.,Nogales, E.,Collins, K. Template and target-site recognition by human LINE-1 in retrotransposition. Nature, 626:186-193, 2024 Cited by PubMed: 38096901 DOI: 10.1038/s41586-023-06933-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation