8UW3
Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | LINE-1 retrotransposable element ORF2 protein | polymer | 1275 | 149300.4 | 1 | UniProt (O00370) Pfam (PF03372) Pfam (PF00078) In PDB | Homo sapiens (human) | |
| 2 | B | Template RNA | polymer | 74 | 23956.5 | 1 | synthetic construct | ||
| 3 | C | Complementary DNA | polymer | 13 | 3951.6 | 1 | synthetic construct | ||
| 4 | A | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) |
Sequence modifications
A: 1 - 1275 (UniProt: O00370)
| PDB | External Database | Details |
|---|---|---|
| Ile 15 | Val 15 | conflict |
| Ala 21 | Pro 21 | conflict |
| Thr 152 | Ile 152 | conflict |
| Ala 175 | Thr 175 | conflict |
| His 305 | Tyr 305 | conflict |
| Lys 431 | Thr 431 | conflict |
| Met 595 | Val 595 | conflict |
| Thr 625 | Met 625 | conflict |
| Phe 627 | Leu 627 | conflict |
| Thr 744 | Asn 744 | conflict |
| Glu 795 | Asp 795 | conflict |
| Phe 932 | Leu 932 | conflict |
| Leu 1141 | Val 1141 | conflict |
| Asn 1182 | Lys 1182 | conflict |
| Glu 1183 | Asp 1183 | conflict |
| Lys 1212 | Asn 1212 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 177208.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 482.2 | |
| All* | Total formula weight | 177690.6 |
