8UW3
Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| A | 0006310 | biological_process | DNA recombination |
| A | 0009036 | molecular_function | type II site-specific deoxyribonuclease activity |
| A | 0032197 | biological_process | retrotransposition |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090304 | biological_process | nucleic acid metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | TYR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P27695 |
| Chain | Residue | Details |
| A | ASP145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17626046, ECO:0000269|PubMed:34554261, ECO:0007744|PDB:2V0S, ECO:0007744|PDB:7N8K |
| Chain | Residue | Details |
| A | GLU43 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00405 |
| Chain | Residue | Details |
| A | ASP600 | |
| A | ASP702 | |
| A | ASP703 |
