8UW3
Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| A | 0006310 | biological_process | DNA recombination |
| A | 0009036 | molecular_function | type II site-specific deoxyribonuclease activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032197 | biological_process | retrotransposition |
| A | 0034061 | molecular_function | DNA polymerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071897 | biological_process | DNA biosynthetic process |
| A | 0090304 | biological_process | nucleic acid metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 275 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Domain: {"description":"DUF1725"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 179 |
| Details | Region: {"description":"Carboxy-terminal segment; binds RNA","evidences":[{"source":"PubMed","id":"24251107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Motif: {"description":"FADD motif","evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17626046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34554261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N8K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
