8UW3

Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
A	0006310	biological_process	DNA recombination
A	0009036	molecular_function	type II site-specific deoxyribonuclease activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0032197	biological_process	retrotransposition
A	0034061	molecular_function	DNA polymerase activity
A	0046872	molecular_function	metal ion binding
A	0071897	biological_process	DNA biosynthetic process
A	0090304	biological_process	nucleic acid metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P27695

Chain	Residue	Details
A	TYR115

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P27695

Chain	Residue	Details
A	ASP145

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17626046, ECO:0000269|PubMed:34554261, ECO:0007744|PDB:2V0S, ECO:0007744|PDB:7N8K

Chain	Residue	Details
A	GLU43

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00405

Chain	Residue	Details
A	ASP600
A	ASP702
A	ASP703

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