3RGF

Crystal Structure of human CDK8/CycC

Summary for 3RGF

• Entry DOI: 10.2210/pdb3rgf/pdb
• Descriptor: Cyclin-dependent kinase 8, Cyclin-C, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ... (6 entities in total)
• Functional Keywords: protein kinase complex, transferase, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Probable): P49336 P24863
• Total number of polymer chains: 2
• Total formula weight: 81710.42

Authors

Schneider, E.V.,Boettcher, J.,Blaesse, M.,Huber, R.,Maskos, K. (deposition date: 2011-04-08, release date: 2011-08-10, Last modification date: 2023-09-13)

• Primary citation: Schneider, E.V.,Bottcher, J.,Blaesse, M.,Neumann, L.,Huber, R.,Maskos, K.; The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder.; J.Mol.Biol., 412:251-266, 2011; PubMed: 21806996; DOI: 10.1016/j.jmb.2011.07.020

Experimental method

X-RAY DIFFRACTION (2.2 Å)