3RGF
Crystal Structure of human CDK8/CycC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 405 | 46990.8 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (human) | CDK8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 285 | 33480.0 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (human) | CYCC, SRB11 homolog, hSRB11 |
| 3 | C (A) | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | non-polymer | 464.8 | 1 | Chemie (BAX) | |||
| 4 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 5 | J (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80470.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1239.7 | |
| All* | Total formula weight | 81710.4 |
