7M0D

Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound complementary DSB substrate and incoming dUMPNPP

Summary for 7M0D

• Entry DOI: 10.2210/pdb7m0d/pdb
• Descriptor: DNA polymerase lambda, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CITRIC ACID, ... (15 entities in total)
• Functional Keywords: nonhomologous end-joining, base excision repair, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 92561.80

Authors

Kaminski, A.M.,Bebenek, K.,Pedersen, L.C.,Kunkel, T.A. (deposition date: 2021-03-10, release date: 2022-03-16, Last modification date: 2023-10-25)

• Primary citation: Kaminski, A.M.,Chiruvella, K.K.,Ramsden, D.A.,Bebenek, K.,Kunkel, T.A.,Pedersen, L.C.; Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.; Nat Commun, 13:3806-3806, 2022; PubMed: 35778389; DOI: 10.1038/s41467-022-31278-4

Experimental method

X-RAY DIFFRACTION (1.8 Å)