3HUB

Human p38 MAP Kinase in Complex with Scios-469

Summary for 3HUB

• Entry DOI: 10.2210/pdb3hub/pdb
• Related: 3GCP 3GCQ 3GCS 3GCU 3GCV 3HUC
• Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, ... (4 entities in total)
• Functional Keywords: dfg-in, glycine-rich loop, scios-469, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42040.35

Authors

Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2009-06-13, release date: 2010-03-09, Last modification date: 2024-02-21)

• Primary citation: Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D.; Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.; J.Am.Chem.Soc., 132:4152-4160, 2010; PubMed: 20201574; DOI: 10.1021/ja908083e

Experimental method

X-RAY DIFFRACTION (2.25 Å)