3GCS
Human P38 MAP kinase in complex with Sorafenib
Summary for 3GCS
Entry DOI | 10.2210/pdb3gcs/pdb |
Related | 3GCQ 3GCU |
Descriptor | Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | dfg-out, type ii, bay439006, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41992.17 |
Authors | Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2009-02-22, release date: 2009-06-09, Last modification date: 2023-09-06) |
Primary citation | Simard, J.R.,Getlik, M.,Grutter, C.,Pawar, V.,Wulfert, S.,Rabiller, M.,Rauh, D. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J.Am.Chem.Soc., 131:13286-13296, 2009 Cited by PubMed: 19572644DOI: 10.1021/ja902010p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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