3HUB
Human p38 MAP Kinase in Complex with Scios-469
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 360 | 41235.0 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
2 | A | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
3 | A | 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide | non-polymer | 513.0 | 1 | Chemie (469) | |||
4 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 2 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 119 | Cys 119 | engineered mutation |
Ser 162 | Cys 162 | engineered mutation |
Cys 172 | Ala 172 | engineered mutation |
Leu 327 | Phe 327 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41235.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 805.4 | |
All* | Total formula weight | 42040.3 |