4LN7

5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease

Summary for 4LN7

• Entry DOI: 10.2210/pdb4ln7/pdb
• Related: 4KIL 4M5O 4M5Q 4M5R 4M5U 4M5V 4MK1 4MK2 4MK5
• Descriptor: POLYMERASE PA, MANGANESE (II) ION, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: cap-snatching, rna binding protein-inhibitor, rna binding protein-inhibitor complex, rna binding protein/inhibitor
• Biological source: INFLUENZA A VIRUS (A/LIMA/WRAIR1695P/2009(H1N1))
• Total number of polymer chains: 1
• Total formula weight: 25310.58

Authors

Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2013-07-11, release date: 2013-09-18, Last modification date: 2024-02-28)

• Primary citation: Bauman, J.D.,Patel, D.,Baker, S.F.,Vijayan, R.S.,Xiang, A.,Parhi, A.K.,Martinez-Sobrido, L.,Lavoie, E.J.,Das, K.,Arnold, E.; Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.; Acs Chem.Biol., 8:2501-2508, 2013; PubMed: 23978130; DOI: 10.1021/cb400400j

Experimental method

X-RAY DIFFRACTION (1.73 Å)