3HUC

Human p38 MAP Kinase in Complex with RL40

Summary for 3HUC

Related3GCP 3GCQ 3GCS 3GCU 3GCV 3HUB
DescriptorMitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide, ... (5 entities in total)
Functional Keywordsdfg-out, glycine-rich loop, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity) Q16539
Total number of polymer chains1
Total molecular weight42113.04
Authors
Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2009-06-13, release date: 2010-03-09, Last modification date: 2011-07-13)
Primary citation
Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D.
Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.
J.Am.Chem.Soc., 132:4152-4160, 2010
PubMed: 20201574 (PDB entries with the same primary citation)
DOI: 10.1021/ja908083e
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.228501.7%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution