5E0V

Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms

Summary for 5E0V

Related1AXC 5E0T 5E0U
DescriptorProliferating cell nuclear antigen, Flap endonuclease 1 (3 entities in total)
Functional Keywordsdna replication, sliding clamp, dna binding protein
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P12004
Mitochondrion . Nucleus, nucleolus  B4DWZ4
Total number of polymer chains4
Total molecular weight61189.57
Authors
Duffy, C.M.,Hilbert, B.J.,Kelch, B.A. (deposition date: 2015-09-29, release date: 2016-04-20, Last modification date: 2017-11-22)
Primary citation
Duffy, C.M.,Hilbert, B.J.,Kelch, B.A.
A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428:1023-1040, 2016
PubMed: 26688547 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2015.11.029
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.074 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22350.2%0.2%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5e0v
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Molmil generated image of 5e0v
rotated about x axis by 90°
Molmil generated image of 5e0v
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 5e0v
no rotation
Molmil generated image of 5e0v
rotated about x axis by 90°
Molmil generated image of 5e0v
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5e0v.pdb1.gz [82.24 KB])
Coordinate files for Biological unit (5e0v.pdb2.gz [81.21 KB])