Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5E0V

Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005652	cellular_component	nuclear lamina
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005813	cellular_component	centrosome
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006298	biological_process	mismatch repair
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007507	biological_process	heart development
A	0016604	cellular_component	nuclear body
A	0019899	molecular_function	enzyme binding
A	0019985	biological_process	translesion synthesis
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030855	biological_process	epithelial cell differentiation
A	0030894	cellular_component	replisome
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031297	biological_process	replication fork processing
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032355	biological_process	response to estradiol
A	0032405	molecular_function	MutLalpha complex binding
A	0033993	biological_process	response to lipid
A	0034644	biological_process	cellular response to UV
A	0035035	molecular_function	histone acetyltransferase binding
A	0042802	molecular_function	identical protein binding
A	0043596	cellular_component	nuclear replication fork
A	0043626	cellular_component	PCNA complex
A	0044849	biological_process	estrous cycle
A	0044877	molecular_function	protein-containing complex binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0046686	biological_process	response to cadmium ion
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070557	cellular_component	PCNA-p21 complex
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071548	biological_process	response to dexamethasone
A	0097421	biological_process	liver regeneration
A	1902065	biological_process	response to L-glutamate
A	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0001673	cellular_component	male germ cell nucleus
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005652	cellular_component	nuclear lamina
B	0005654	cellular_component	nucleoplasm
B	0005657	cellular_component	replication fork
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006298	biological_process	mismatch repair
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007507	biological_process	heart development
B	0016604	cellular_component	nuclear body
B	0019899	molecular_function	enzyme binding
B	0019985	biological_process	translesion synthesis
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0030855	biological_process	epithelial cell differentiation
B	0030894	cellular_component	replisome
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031297	biological_process	replication fork processing
B	0032139	molecular_function	dinucleotide insertion or deletion binding
B	0032355	biological_process	response to estradiol
B	0032405	molecular_function	MutLalpha complex binding
B	0033993	biological_process	response to lipid
B	0034644	biological_process	cellular response to UV
B	0035035	molecular_function	histone acetyltransferase binding
B	0042802	molecular_function	identical protein binding
B	0043596	cellular_component	nuclear replication fork
B	0043626	cellular_component	PCNA complex
B	0044849	biological_process	estrous cycle
B	0044877	molecular_function	protein-containing complex binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045740	biological_process	positive regulation of DNA replication
B	0046686	biological_process	response to cadmium ion
B	0070062	cellular_component	extracellular exosome
B	0070182	molecular_function	DNA polymerase binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070557	cellular_component	PCNA-p21 complex
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071548	biological_process	response to dexamethasone
B	0097421	biological_process	liver regeneration
B	1902065	biological_process	response to L-glutamate
B	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
A	ARG61-LEU79

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
A	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	186
Details	Region: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Region: {"description":"Interaction with PCNA","evidences":[{"source":"PubMed","id":"9305916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)