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8RBZ
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BU of 8rbz by Molmil
Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Descriptor: DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ...
Authors:Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P.
Deposit date:2023-12-05
Release date:2024-02-07
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
8SO0
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BU of 8so0 by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex
Descriptor: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-04-28
Release date:2023-10-25
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.79961 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8SW5
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BU of 8sw5 by Molmil
Protein Phosphatase 1 in complex with PP1-specific Phosphatase targeting peptide (PhosTAP) version 1
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, PP1-specific Phosphatase-Targeting Peptide version 1, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2023-05-17
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:A Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome
To Be Published
8SW6
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BU of 8sw6 by Molmil
Protein Phosphatase 1 in complex with PP1-specific Phosphatase targeting peptide (PhosTAP) version 3
Descriptor: CHLORIDE ION, MANGANESE (II) ION, PP1-specific Phosphatase-Targeting Peptide version 3, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2023-05-17
Release date:2024-05-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome
To Be Published
8TWI
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BU of 8twi by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
Descriptor: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-21
Release date:2023-11-01
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8TWE
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BU of 8twe by Molmil
Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
Descriptor: PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-21
Release date:2023-11-01
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8TTB
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BU of 8ttb by Molmil
Cryo-EM structure of the PP2A:B55-ARPP19 complex
Descriptor: FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Fuller, J.R, Padi, S.K.R, Peti, W, Page, R.
Deposit date:2023-08-13
Release date:2023-10-25
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
8U5G
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BU of 8u5g by Molmil
Crystal structure of the co-expressed SDS22:PP1:I3 complex
Descriptor: E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2023-09-12
Release date:2023-12-06
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange.
J.Biol.Chem., 300, 2023
8U89
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BU of 8u89 by Molmil
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Wu, C.G, Xing, Y.
Deposit date:2023-09-16
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
8U1X
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BU of 8u1x by Molmil
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Wu, C.G, Xing, Y.
Deposit date:2023-09-04
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proc.Natl.Acad.Sci.USA, 121, 2024
7SD0
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BU of 7sd0 by Molmil
Cryo-EM structure of the SHOC2:PP1C:MRAS complex
Descriptor: Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J.
Deposit date:2021-09-29
Release date:2022-04-20
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for SHOC2 modulation of RAS signalling.
Nature, 609, 2022
7YCX
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BU of 7ycx by Molmil
The structure of INTAC-PEC complex
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y.
Deposit date:2022-07-02
Release date:2023-03-15
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Structural basis of INTAC-regulated transcription.
Protein Cell, 14, 2023
4V0U
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BU of 4v0u by Molmil
The crystal structure of ternary PP1G-PPP1R15B and G-actin complex
Descriptor: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J.
Deposit date:2014-09-18
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (7.88 Å)
Cite:G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
8GAE
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BU of 8gae by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-02-22
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
8GFT
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BU of 8gft by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-03-08
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
7ZR5
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BU of 7zr5 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7ZR6
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BU of 7zr6 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
8B5R
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BU of 8b5r by Molmil
p97-p37-SPI substrate complex
Descriptor: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ...
Authors:van den Boom, J, Marini, G, Meyer, H, Saibil, H.
Deposit date:2022-09-24
Release date:2023-06-07
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
7SQC
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BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
7TVF
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BU of 7tvf by Molmil
Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom
Descriptor: CHLORIDE ION, GLYCEROL, Leucine-rich repeat protein SHOC-2, ...
Authors:Bonsor, D.A, Simanshu, D.K.
Deposit date:2022-02-04
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Nat.Struct.Mol.Biol., 29, 2022
7TXH
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BU of 7txh by Molmil
Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca
Descriptor: GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ...
Authors:Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M.
Deposit date:2022-02-09
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature, 609, 2022
7UPI
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BU of 7upi by Molmil
Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex
Descriptor: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ...
Authors:Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A.
Deposit date:2022-04-15
Release date:2022-05-04
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Nature, 609, 2022
6GHM
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BU of 6ghm by Molmil
Structure of PP1 alpha phosphatase bound to ASPP2
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ...
Authors:Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y.
Deposit date:2018-05-08
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.
Nat Commun, 10, 2019
4IL1
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BU of 4il1 by Molmil
Crystal Structure of the Rat Calcineurin
Descriptor: CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ...
Authors:Ye, Q, Faucher, F, Jia, Z.
Deposit date:2012-12-28
Release date:2013-10-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of calcineurin activation by calmodulin.
Cell Signal, 25, 2013
7N6G
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BU of 7n6g by Molmil
C1 of central pair
Descriptor: CPC1, Calmodulin, DPY30, ...
Authors:Han, L, Zhang, K.
Deposit date:2021-06-08
Release date:2022-05-18
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022

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