8TWI

Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body

Summary for 8TWI

• Entry DOI: 10.2210/pdb8twi/pdb
• Related: 8SO0
• EMDB information: 40644 41668
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, ... (5 entities in total)
• Functional Keywords: protein phosphatase 2a:b55 holoenzyme fam122a inhibitor substrate binding cell cycle regulation, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 111605.52

Authors

Fuller, J.R.,Padi, S.K.R.,Peti, W.,Page, R. (deposition date: 2023-08-21, release date: 2023-11-01, Last modification date: 2024-01-17)

• Primary citation: Padi, S.K.R.,Vos, M.R.,Godek, R.J.,Fuller, J.R.,Kruse, T.,Hein, J.B.,Nilsson, J.,Kelker, M.S.,Page, R.,Peti, W.; Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.; Nature, 625:195-203, 2024; PubMed: 38123684; DOI: 10.1038/s41586-023-06870-3

Experimental method

ELECTRON MICROSCOPY (2.69 Å)