8U89

The structure of the PP2A-B56Delta holoenzyme mutant - E197K

Summary for 8U89

• Entry DOI: 10.2210/pdb8u89/pdb
• EMDB information: 42018
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (4 entities in total)
• Functional Keywords: complex, phosphatase, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 171214.11

Authors

Wu, C.G.,Xing, Y. (deposition date: 2023-09-16, release date: 2024-01-10)

• Primary citation: Wu, C.G.,Balakrishnan, V.K.,Merrill, R.A.,Parihar, P.S.,Konovolov, K.,Chen, Y.C.,Xu, Z.,Wei, H.,Sundaresan, R.,Cui, Q.,Wadzinski, B.E.,Swingle, M.R.,Musiyenko, A.,Chung, W.K.,Honkanen, R.E.,Suzuki, A.,Huang, X.,Strack, S.,Xing, Y.; B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.; Proc.Natl.Acad.Sci.USA, 121:e2310727120-e2310727120, 2024; PubMed: 38150499; DOI: 10.1073/pnas.2310727120

Experimental method

ELECTRON MICROSCOPY (3.3 Å)