8U89
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 589 | 65378.3 | 1 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
| 2 | B (B) | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | polymer | 602 | 70089.7 | 1 | UniProt (Q14738) Pfam (PF01603) | Homo sapiens (human) | |
| 3 | C (C) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35636.2 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | PP2A-alpha,Replication protein C,RP-C |
| 4 | D, E (C) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
B: 1 - 602 (UniProt: Q14738)
| PDB | External Database | Details |
|---|---|---|
| Lys 197 | Glu 197 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 171104.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 109.9 | |
| All* | Total formula weight | 171214.1 |
